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- W2078803436 abstract "1 The change of the optical rotatory dispersion spectra as a function of pH of DNAs of different base composition and the synthetic polynucleotides poly d(A–T) and poly (dG) · poly (dC) has been studied. 2 It is shown that the acid titration of DNA when followed by optical rotatory dispersion is considerably more complex than it appears from ultraviolet absorption data. The gradual appearance of a peak at 260–270 mμ between pH 3 and 4 before acid denaturation, indicates a change of conformation of the guanosine residues in this pH region. 3 DNA methylated in N-7 of guanine does not show this inversion of Cotton effects. It is concluded that this position plays an important role in the acid titration of DNA. 4 Protonation on N-7 of guanine, rotation of guanine out of the helix, reversion into the syn-position, pairing in Hoogsteen manner and thus sharing the proton with N-1 on cytosine is suggested as a possible interpretation of these results. 5 From the data presented it is concluded that poly (dG) · poly (dC) has a conformation and/or structure different from that of DNA (B-form). In analogy with published data on nucleo-sides, it is suggested that guanosine is in the syn-conformation. Three possible structures seem to be feasible: (a) Watson-Crick pairing with parallel strands; (b) Hoogsteen pairing with anti-parallel strands; (c) Watson-Crick pairing with antiparallel strands in a left handed helix." @default.
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- W2078803436 date "1968-12-01" @default.
- W2078803436 modified "2023-10-04" @default.
- W2078803436 title "Protonated Polynucleotide Structures. 3. An Optical Rotatory Dispersion Study of the Protonation of DNA" @default.
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- W2078803436 doi "https://doi.org/10.1111/j.1432-1033.1968.tb00472.x" @default.
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