FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078804130> ?p ?o ?g. }

• W2078804130 endingPage "81" @default.
• W2078804130 startingPage "70" @default.
• W2078804130 abstract "INTRODUCTION AND OBJECTIVES To investigate the role of E2F/RB in androgen independent proliferation, differentiation, and sensitivity to apoptotic stimuli of LNCaP prostate cancer cells. METHODS The effects of E2F1 overexpression on androgen independent proliferation, differentiation, and apoptotic responses was assessed by flow cytometry, Western blot analysis and staining of nuclei. RESULTS Overexpression of E2F1 in LNCaP cells confers resistance to an androgen withdrawal-mediated growth arrest, prevents differentiation, and modifies apoptotic responses. Androgen independent proliferation is associated with a dose dependent elevation of cyclin E. Cells expressing high levels of E2F1 continue to express androgen receptor and have a diminished expression of neuronal specific enolase when cultured in androgen-depleted media. Additionally, E2F1-expressing cells are more sensitive to etoposide-induced apoptosis. Western blot analysis revealed that LNCaP-E2F1 cells have elevated expression of p73, Apaf-1, caspase-3, caspase-7, but expression of caspase-8 and -9, p14(ARF), and Mcl-1, is unaltered. CONCLUSION This is the first study that describes E2F1-dependent modifications of androgen dependence, differentiation, and sensitivity to apoptotic stimuli in LNCaP cells. Our analysis also identifies a subset of E2F1 targets that are instrumental in altering proliferative, differentiation, and apoptotic properties. Deregulation of the E2F/RB pathway and subsequent modification of key regulatory proteins may promote the development of hormone-refractory prostate tumors. Published 2005 Wiley-Liss, Inc." @default.
• W2078804130 created "2016-06-24" @default.
• W2078804130 creator A5000966901 @default.
• W2078804130 creator A5010752073 @default.
• W2078804130 creator A5014332343 @default.
• W2078804130 creator A5043311357 @default.
• W2078804130 creator A5045283992 @default.
• W2078804130 creator A5061878287 @default.
• W2078804130 date "2006-01-01" @default.
• W2078804130 modified "2023-09-29" @default.
• W2078804130 title "E2F1 expression in LNCaP prostate cancer cells deregulates androgen dependent growth, suppresses differentiation, and enhances apoptosis" @default.
• W2078804130 cites W1497251274 @default.
• W2078804130 cites W1520563041 @default.
• W2078804130 cites W1527058604 @default.
• W2078804130 cites W1634638391 @default.
• W2078804130 cites W1874270646 @default.
• W2078804130 cites W1964545908 @default.
• W2078804130 cites W1965080968 @default.
• W2078804130 cites W1970778306 @default.
• W2078804130 cites W1975042281 @default.
• W2078804130 cites W1976485192 @default.
• W2078804130 cites W1980416901 @default.
• W2078804130 cites W1983971803 @default.
• W2078804130 cites W1996759876 @default.
• W2078804130 cites W2001411531 @default.
• W2078804130 cites W2007796732 @default.
• W2078804130 cites W2008797552 @default.
• W2078804130 cites W2009348177 @default.
• W2078804130 cites W2011580644 @default.
• W2078804130 cites W2024950200 @default.
• W2078804130 cites W2029080338 @default.
• W2078804130 cites W2034269086 @default.
• W2078804130 cites W2034277114 @default.
• W2078804130 cites W2040056274 @default.
• W2078804130 cites W2049777428 @default.
• W2078804130 cites W2049783958 @default.
• W2078804130 cites W2054045654 @default.
• W2078804130 cites W2055162988 @default.
• W2078804130 cites W2059660113 @default.
• W2078804130 cites W2062856452 @default.
• W2078804130 cites W2066125587 @default.
• W2078804130 cites W2066469256 @default.
• W2078804130 cites W2071373462 @default.
• W2078804130 cites W2074432871 @default.
• W2078804130 cites W2074920283 @default.
• W2078804130 cites W2080773971 @default.
• W2078804130 cites W2087450028 @default.
• W2078804130 cites W2094249595 @default.
• W2078804130 cites W2102735328 @default.
• W2078804130 cites W2105902888 @default.
• W2078804130 cites W2108974866 @default.
• W2078804130 cites W2119683782 @default.
• W2078804130 cites W2125538315 @default.
• W2078804130 cites W2137433289 @default.
• W2078804130 cites W2144701362 @default.
• W2078804130 cites W2149139293 @default.
• W2078804130 cites W2152616419 @default.
• W2078804130 cites W2166201219 @default.
• W2078804130 cites W2166668167 @default.
• W2078804130 cites W2172249054 @default.
• W2078804130 cites W2319353003 @default.
• W2078804130 cites W2321525112 @default.
• W2078804130 cites W2411214717 @default.
• W2078804130 cites W4252154305 @default.
• W2078804130 cites W4376849754 @default.
• W2078804130 doi "https://doi.org/10.1002/pros.20314" @default.
• W2078804130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16114066" @default.
• W2078804130 hasPublicationYear "2006" @default.
• W2078804130 type Work @default.
• W2078804130 sameAs 2078804130 @default.
• W2078804130 citedByCount "33" @default.
• W2078804130 countsByYear W20788041302013 @default.
• W2078804130 countsByYear W20788041302015 @default.
• W2078804130 countsByYear W20788041302016 @default.
• W2078804130 countsByYear W20788041302018 @default.
• W2078804130 countsByYear W20788041302019 @default.
• W2078804130 countsByYear W20788041302020 @default.
• W2078804130 countsByYear W20788041302021 @default.
• W2078804130 countsByYear W20788041302022 @default.
• W2078804130 countsByYear W20788041302023 @default.
• W2078804130 crossrefType "journal-article" @default.
• W2078804130 hasAuthorship W2078804130A5000966901 @default.
• W2078804130 hasAuthorship W2078804130A5010752073 @default.
• W2078804130 hasAuthorship W2078804130A5014332343 @default.
• W2078804130 hasAuthorship W2078804130A5043311357 @default.
• W2078804130 hasAuthorship W2078804130A5045283992 @default.
• W2078804130 hasAuthorship W2078804130A5061878287 @default.
• W2078804130 hasConcept C121608353 @default.
• W2078804130 hasConcept C126322002 @default.
• W2078804130 hasConcept C134018914 @default.
• W2078804130 hasConcept C183022183 @default.
• W2078804130 hasConcept C190283241 @default.
• W2078804130 hasConcept C2777911890 @default.
• W2078804130 hasConcept C2779723316 @default.
• W2078804130 hasConcept C2780192828 @default.
• W2078804130 hasConcept C29537977 @default.
• W2078804130 hasConcept C502942594 @default.
• W2078804130 hasConcept C54355233 @default.

• next