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- W2078805137 abstract "Huntingtin-associated protein 1 (HAP1) is an essential component of the stigmoid body (STB) and known as a possible neuroprotective interactor with causative proteins for Huntington's disease, spinal and bulbar muscular atrophy, spinocerebellar ataxia type 17 (SCA17), and Joubert syndrome. To clarify what other causative molecules HAP1/STB could interact with, we cloned normal causative genes for several neural disorders from human brain RNA library and evaluated their subcellular interaction with HAP1/STB by immunocytochemistry and immunoprecipitation after cotransfection into Neuro2a cells. The results clearly showed that HAP1/STB interacts with the normal ataxin-3 through Josephin domain and polyglutamine-expanded mutants derived from SCA3 as well. The findings suggest that HAP1/STB could modify the physiological function of normal ataxin-3 and pathogenesis of SCA3 attributable to the mutant ataxin-3." @default.
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- W2078805137 date "2011-03-30" @default.
- W2078805137 modified "2023-09-26" @default.
- W2078805137 title "Interaction of ataxin-3 with huntingtin-associated protein 1 through Josephin domain" @default.
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- W2078805137 doi "https://doi.org/10.1097/wnr.0b013e32834505f4" @default.
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