FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078808411> ?p ?o ?g. }

• W2078808411 endingPage "674" @default.
• W2078808411 startingPage "674" @default.
• W2078808411 abstract "<h3>Context</h3>Vitamin D is associated with decreased cardiovascular-related morbidity and mortality, possibly by modifying cardiac structure and function, yet firm evidence for either remains lacking.<h3>Objective</h3>To determine the effects of an active vitamin D compound, paricalcitol, on left ventricular mass over 48 weeks in patients with an estimated glomerular filtration rate of 15 to 60 mL/min/1.73 m².<h3>Design, Setting, and Participants</h3>Multinational, double-blind, randomized placebo-controlled trial among 227 patients with chronic kidney disease, mild to moderate left ventricular hypertrophy, and preserved left ventricular ejection fraction, conducted in 11 countries from July 2008 through September 2010.<h3>Intervention</h3>Participants were randomly assigned to receive oral paricalcitol, 2 μg/d (n =115), or matching placebo (n = 112).<h3>Main Outcome Measures</h3>Change in left ventricular mass index over 48 weeks by cardiovascular magnetic resonance imaging. Secondary end points included echocardiographic changes in left ventricular diastolic function.<h3>Results</h3>Treatment with paricalcitol reduced parathyroid hormone levels within 4 weeks and maintained levels within the normal range throughout the study duration. At 48 weeks, the change in left ventricular mass index did not differ between treatment groups (paricalcitol group, 0.34 g/m^2.7 [95% CI, −0.14 to 0.83 g/m^2.7] vs placebo group, −0.07 g/m^2.7 [95% CI, −0.55 to 0.42 g/m^2.7]). Doppler measures of diastolic function including peak early diastolic lateral mitral annular tissue velocity (paricalcitol group, −0.01 cm/s [95% CI, −0.63 to 0.60 cm/s] vs placebo group, −0.30 cm/s [95% CI, −0.93 to 0.34 cm/s]) also did not differ. Episodes of hypercalcemia were more frequent in the paricalcitol group compared with the placebo group.<h3>Conclusion</h3>Forty-eight week therapy with paricalcitol did not alter left ventricular mass index or improve certain measures of diastolic dysfunction in patients with chronic kidney disease.<h3>Trial Registration</h3>clinicaltrials.gov Identifier: NCT00497146" @default.
• W2078808411 created "2016-06-24" @default.
• W2078808411 creator A5002927848 @default.
• W2078808411 creator A5016018137 @default.
• W2078808411 creator A5016269889 @default.
• W2078808411 creator A5017418373 @default.
• W2078808411 creator A5018746870 @default.
• W2078808411 creator A5033368647 @default.
• W2078808411 creator A5034584090 @default.
• W2078808411 creator A5038371805 @default.
• W2078808411 creator A5041339585 @default.
• W2078808411 creator A5050981927 @default.
• W2078808411 creator A5051708137 @default.
• W2078808411 creator A5051761992 @default.
• W2078808411 creator A5054404109 @default.
• W2078808411 creator A5054830306 @default.
• W2078808411 creator A5055915308 @default.
• W2078808411 creator A5058434023 @default.
• W2078808411 creator A5063645025 @default.
• W2078808411 creator A5065997346 @default.
• W2078808411 creator A5068654431 @default.
• W2078808411 creator A5070200665 @default.
• W2078808411 creator A5075161165 @default.
• W2078808411 creator A5087076023 @default.
• W2078808411 date "2012-02-15" @default.
• W2078808411 modified "2023-09-27" @default.
• W2078808411 title "Vitamin D Therapy and Cardiac Structure and Function in Patients With Chronic Kidney Disease" @default.
• W2078808411 cites W1597964526 @default.
• W2078808411 cites W1964816689 @default.
• W2078808411 cites W1968424160 @default.
• W2078808411 cites W1968716992 @default.
• W2078808411 cites W1969369541 @default.
• W2078808411 cites W1979733976 @default.
• W2078808411 cites W1990068444 @default.
• W2078808411 cites W1998134891 @default.
• W2078808411 cites W2001320196 @default.
• W2078808411 cites W2003162718 @default.
• W2078808411 cites W2003745777 @default.
• W2078808411 cites W2007147524 @default.
• W2078808411 cites W2018398979 @default.
• W2078808411 cites W2023213178 @default.
• W2078808411 cites W2031551169 @default.
• W2078808411 cites W2031580436 @default.
• W2078808411 cites W2032317372 @default.
• W2078808411 cites W2035221187 @default.
• W2078808411 cites W2036526711 @default.
• W2078808411 cites W2037583569 @default.
• W2078808411 cites W2040421189 @default.
• W2078808411 cites W2043112285 @default.
• W2078808411 cites W2049893341 @default.
• W2078808411 cites W2052115455 @default.
• W2078808411 cites W2059531072 @default.
• W2078808411 cites W2061503267 @default.
• W2078808411 cites W2066990527 @default.
• W2078808411 cites W2069534468 @default.
• W2078808411 cites W2071421225 @default.
• W2078808411 cites W2072563180 @default.
• W2078808411 cites W2073789348 @default.
• W2078808411 cites W2077266216 @default.
• W2078808411 cites W2081499390 @default.
• W2078808411 cites W2101099004 @default.
• W2078808411 cites W2103326270 @default.
• W2078808411 cites W2105417592 @default.
• W2078808411 cites W2107072401 @default.
• W2078808411 cites W2107195787 @default.
• W2078808411 cites W2109649607 @default.
• W2078808411 cites W2110152372 @default.
• W2078808411 cites W2113356410 @default.
• W2078808411 cites W2113748378 @default.
• W2078808411 cites W2117913791 @default.
• W2078808411 cites W2118795360 @default.
• W2078808411 cites W2119846536 @default.
• W2078808411 cites W2123338619 @default.
• W2078808411 cites W2124070987 @default.
• W2078808411 cites W2136476728 @default.
• W2078808411 cites W2136566853 @default.
• W2078808411 cites W2137848126 @default.
• W2078808411 cites W2148873853 @default.
• W2078808411 cites W2150171276 @default.
• W2078808411 cites W2151607420 @default.
• W2078808411 cites W2162129240 @default.
• W2078808411 cites W2163182278 @default.
• W2078808411 cites W2165433745 @default.
• W2078808411 cites W2166775378 @default.
• W2078808411 cites W2169588753 @default.
• W2078808411 cites W2171361977 @default.
• W2078808411 cites W633735835 @default.
• W2078808411 cites W65718997 @default.
• W2078808411 cites W95757849 @default.
• W2078808411 doi "https://doi.org/10.1001/jama.2012.120" @default.
• W2078808411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22337679" @default.
• W2078808411 hasPublicationYear "2012" @default.
• W2078808411 type Work @default.
• W2078808411 sameAs 2078808411 @default.
• W2078808411 citedByCount "497" @default.
• W2078808411 countsByYear W20788084112012 @default.
• W2078808411 countsByYear W20788084112013 @default.
• W2078808411 countsByYear W20788084112014 @default.

• next