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• W2078826554 endingPage "602" @default.
• W2078826554 startingPage "591" @default.
• W2078826554 abstract "Transforming growth factor-alpha (TGF-alpha) is a member of the EGF growth factor family. Both transmembrane TGF-alpha and the proteolytically released soluble TGF-alpha can bind to the EGF/TGF-alpha tyrosine kinase receptor (EGFR) and activate the EGFR-induced signaling pathways. We now demonstrate that transmembrane TGF-alpha physically interacts with CD9, a protein with four membrane spanning domains that is frequently coexpressed with TGF-alpha in carcinomas. This interaction was mediated through the extracellular domain of transmembrane TGF-alpha. CD9 expression strongly decreased the growth factor- and PMA- induced proteolytic conversions of transmembrane to soluble TGF-alpha and strongly enhanced the TGF- alpha-induced EGFR activation, presumably in conjunction with increased expression of transmembrane TGF-alpha. In juxtacrine assays, the CD9-induced EGFR hyperactivation by transmembrane TGF-alpha resulted in increased proliferation. In contrast, CD9 coexpression with transmembrane TGF-alpha decreased the autocrine growth stimulatory effect of TGF-alpha in epithelial cells. This decrease was associated with increased expression of the cdk inhibitor, p21(CIP1). These data reveal that the association of CD9 with transmembrane TGF-alpha regulates ligand-induced activation of the EGFR, and results in altered cell proliferation." @default.
• W2078826554 created "2016-06-24" @default.
• W2078826554 creator A5019617084 @default.
• W2078826554 creator A5068725149 @default.
• W2078826554 creator A5070098548 @default.
• W2078826554 creator A5089610748 @default.
• W2078826554 date "2000-02-07" @default.
• W2078826554 modified "2023-10-15" @default.
• W2078826554 title "The Tetraspanin Cd9 Associates with Transmembrane TGF-α and Regulates TGF-α–Induced Egf Receptor Activation and Cell Proliferation" @default.
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• W2078826554 doi "https://doi.org/10.1083/jcb.148.3.591" @default.
• W2078826554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2174814" @default.
• W2078826554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10662783" @default.
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