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- W2078852065 abstract "Abstract Axons are linked to induction of myelination during development and to the maintenance of myelin and myelinated tracts in the adult CNS. Currently, it is unknown whether and how axonal plasticity in adult CNS impacts the myelinating cells and their precursors. In this article, we report that newly formed axonal sprouts are able to induce a protracted myelination response in adult CNS. We show that newly formed axonal sprouts, induced by lesion of the entorhino–hippocampal perforant pathway, have the ability to induce a myelination response in stratum radiatum and lucidum CA3. The lesion resulted in significant recruitment of newly formed myelinating cells, documented by incorporation of the proliferation marker bromodeoxyuridine into chondroitin sulphate NG2 expressing cells in stratum radiatum and lucidum CA3 early after lesion, and the occurrence of a 28% increase in the number of oligodendrocytes, of which some had incorporated bromodeoxyuridine, 9 weeks post‐lesion. Additionally, a marked increase (41%) in myelinated fibres was detected in silver stained sections. Interestingly, these apparently new fibres achieved the same axon diameter as unlesioned mice but myelin thickness remained thinner than normal, suggesting that the sprouting axons in stratum radiatum and lucidum CA3 were not fully myelinated 9 weeks after lesion. Our combined results show that sprouting axons provide a strong stimulus to oligodendrocyte lineage cells to engage actively in the myelination processes in the adult CNS. © 2009 Wiley‐Liss, Inc." @default.
- W2078852065 created "2016-06-24" @default.
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- W2078852065 date "2009-05-19" @default.
- W2078852065 modified "2023-10-12" @default.
- W2078852065 title "Axonal plasticity elicits long-term changes in oligodendroglia and myelinated fibers" @default.
- W2078852065 cites W1524211161 @default.
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- W2078852065 cites W1596691011 @default.
- W2078852065 cites W1964382412 @default.
- W2078852065 cites W1974869833 @default.
- W2078852065 cites W1975447828 @default.
- W2078852065 cites W1977633829 @default.
- W2078852065 cites W1979356890 @default.
- W2078852065 cites W1979686107 @default.
- W2078852065 cites W1984035321 @default.
- W2078852065 cites W1984325684 @default.
- W2078852065 cites W1985678908 @default.
- W2078852065 cites W1985850221 @default.
- W2078852065 cites W1988982755 @default.
- W2078852065 cites W1989240666 @default.
- W2078852065 cites W1989764402 @default.
- W2078852065 cites W1993269481 @default.
- W2078852065 cites W2005001826 @default.
- W2078852065 cites W2010395737 @default.
- W2078852065 cites W2015464362 @default.
- W2078852065 cites W2020315449 @default.
- W2078852065 cites W2023367024 @default.
- W2078852065 cites W2023588733 @default.
- W2078852065 cites W2023634037 @default.
- W2078852065 cites W2023693164 @default.
- W2078852065 cites W2023804327 @default.
- W2078852065 cites W2026893520 @default.
- W2078852065 cites W2027815080 @default.
- W2078852065 cites W2027953622 @default.
- W2078852065 cites W2033835887 @default.
- W2078852065 cites W2034994918 @default.
- W2078852065 cites W2037367554 @default.
- W2078852065 cites W2038757125 @default.
- W2078852065 cites W2045451702 @default.
- W2078852065 cites W2045534904 @default.
- W2078852065 cites W2055526424 @default.
- W2078852065 cites W2056575007 @default.
- W2078852065 cites W2060568333 @default.
- W2078852065 cites W2062030300 @default.
- W2078852065 cites W2067705214 @default.
- W2078852065 cites W2068741908 @default.
- W2078852065 cites W2069485678 @default.
- W2078852065 cites W2073611490 @default.
- W2078852065 cites W2073699108 @default.
- W2078852065 cites W2078648149 @default.
- W2078852065 cites W2080534886 @default.
- W2078852065 cites W2081829522 @default.
- W2078852065 cites W2085638769 @default.
- W2078852065 cites W2097849969 @default.
- W2078852065 cites W2105619265 @default.
- W2078852065 cites W2107589629 @default.
- W2078852065 cites W2111405228 @default.
- W2078852065 cites W2113404473 @default.
- W2078852065 cites W2114459543 @default.
- W2078852065 cites W2118746021 @default.
- W2078852065 cites W2119260372 @default.
- W2078852065 cites W2125650861 @default.
- W2078852065 cites W2128979512 @default.
- W2078852065 cites W2131619765 @default.
- W2078852065 cites W2154439602 @default.
- W2078852065 cites W2155716545 @default.
- W2078852065 cites W2156408752 @default.
- W2078852065 cites W2158953306 @default.
- W2078852065 cites W2167181852 @default.
- W2078852065 cites W2167187684 @default.
- W2078852065 cites W2169926615 @default.
- W2078852065 cites W2325038063 @default.
- W2078852065 cites W4294730393 @default.
- W2078852065 cites W4322701624 @default.
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- W2078852065 doi "https://doi.org/10.1002/glia.20897" @default.
- W2078852065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19455714" @default.
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