FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078887787> ?p ?o ?g. }

• W2078887787 endingPage "344" @default.
• W2078887787 startingPage "335" @default.
• W2078887787 abstract "Chronic osteoarthritis (OA) is a degenerative disease of the articular cartilage. DNA-binding high mobility group protein B1 (HMGB1) is released on cellular death/activation and acts as an endogenous danger signal and a proinflammatory cytokine. Matrix metalloproteinase (MMP)-2 and in MMP-9 are induced to mediate proteolytic degradation/remodelling of joint tissues. Collagen degradation in the bone and synovium leads to release of type I collagen-derived cross-linked carboxy-terminal telopeptide (ICTP). These molecules have been linked to the pathogenesis of OA and could have potential as synovial fluid (SF) biomarkers in OA. Cartilage and SF were obtained from 27 dairy bulls (30–61 months old) and control cartilage from six young healthy dairy bulls. OA lesions were evaluated grossly (five grades), histologically (seven Osteoarthritis Research Society International [ORSI] grades) and immunohistochemically (four HMGB1 grades). The OARSI lesion score was calculated as the product of the OARSI grade and the OARSI score (the total area of the lesions). SF concentrations of HMGB1, MMP-2 and -9 and ICTP were measured by enzyme-linked immunosorbent assay, gelatin zymography and radioimmunoassay, respectively. Seventy-two percent (39/54) of stifle joints and 85% (23/27) of the dairy bulls had at least one gross OA lesion and 94% of the lesions were localized to the distal end of the femur, with the patellar groove and the lateral trochlear ridge being predilection sites. Gross and histological grades correlated with the HMGB1 grade, but SF total cell count, percent neutrophils or the measured biomarkers did not correlate with the tissue lesions, with the exception of ICTP concentration, which correlated with the total joint score. The switch of HMGB1 from DNA-binding nuclear protein to an extracellular alarmin/cytokine correlates with the gross and histological grades of OA tissue lesions. However, the activity and extent of the tissue lesions did not correlate with other SF biomarkers, perhaps because the histological grades represent outcome measures, while SF reflects process parameters. The only exception was ICTP concentration, which reflects enhanced destruction/remodelling." @default.
• W2078887787 created "2016-06-24" @default.
• W2078887787 creator A5005564255 @default.
• W2078887787 creator A5012890854 @default.
• W2078887787 creator A5025399664 @default.
• W2078887787 creator A5044835238 @default.
• W2078887787 creator A5050963625 @default.
• W2078887787 creator A5059483196 @default.
• W2078887787 creator A5085896293 @default.
• W2078887787 date "2013-05-01" @default.
• W2078887787 modified "2023-09-29" @default.
• W2078887787 title "Bovine Chronic Osteoarthritis Causes Minimal Change in Synovial Fluid" @default.
• W2078887787 cites W1512868150 @default.
• W2078887787 cites W1595115453 @default.
• W2078887787 cites W1972422985 @default.
• W2078887787 cites W1999080226 @default.
• W2078887787 cites W2004266769 @default.
• W2078887787 cites W2005225387 @default.
• W2078887787 cites W2010763897 @default.
• W2078887787 cites W2022619943 @default.
• W2078887787 cites W2023288212 @default.
• W2078887787 cites W2024221643 @default.
• W2078887787 cites W2025169684 @default.
• W2078887787 cites W2040664046 @default.
• W2078887787 cites W2042107891 @default.
• W2078887787 cites W2042856599 @default.
• W2078887787 cites W2043584926 @default.
• W2078887787 cites W2045910665 @default.
• W2078887787 cites W2050824109 @default.
• W2078887787 cites W2083839389 @default.
• W2078887787 cites W2088755726 @default.
• W2078887787 cites W2089536489 @default.
• W2078887787 cites W2093627523 @default.
• W2078887787 cites W2099260852 @default.
• W2078887787 cites W2099427592 @default.
• W2078887787 cites W2103224375 @default.
• W2078887787 cites W2105873677 @default.
• W2078887787 cites W2116231648 @default.
• W2078887787 cites W2147237892 @default.
• W2078887787 cites W2164714222 @default.
• W2078887787 cites W2256999065 @default.
• W2078887787 doi "https://doi.org/10.1016/j.jcpa.2012.08.001" @default.
• W2078887787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23063106" @default.
• W2078887787 hasPublicationYear "2013" @default.
• W2078887787 type Work @default.
• W2078887787 sameAs 2078887787 @default.
• W2078887787 citedByCount "16" @default.
• W2078887787 countsByYear W20788877872014 @default.
• W2078887787 countsByYear W20788877872015 @default.
• W2078887787 countsByYear W20788877872016 @default.
• W2078887787 countsByYear W20788877872017 @default.
• W2078887787 countsByYear W20788877872018 @default.
• W2078887787 countsByYear W20788877872019 @default.
• W2078887787 countsByYear W20788877872020 @default.
• W2078887787 countsByYear W20788877872023 @default.
• W2078887787 crossrefType "journal-article" @default.
• W2078887787 hasAuthorship W2078887787A5005564255 @default.
• W2078887787 hasAuthorship W2078887787A5012890854 @default.
• W2078887787 hasAuthorship W2078887787A5025399664 @default.
• W2078887787 hasAuthorship W2078887787A5044835238 @default.
• W2078887787 hasAuthorship W2078887787A5050963625 @default.
• W2078887787 hasAuthorship W2078887787A5059483196 @default.
• W2078887787 hasAuthorship W2078887787A5085896293 @default.
• W2078887787 hasConcept C105702510 @default.
• W2078887787 hasConcept C125870589 @default.
• W2078887787 hasConcept C126322002 @default.
• W2078887787 hasConcept C131075544 @default.
• W2078887787 hasConcept C134018914 @default.
• W2078887787 hasConcept C142724271 @default.
• W2078887787 hasConcept C160160445 @default.
• W2078887787 hasConcept C164027704 @default.
• W2078887787 hasConcept C181199279 @default.
• W2078887787 hasConcept C185592680 @default.
• W2078887787 hasConcept C197534660 @default.
• W2078887787 hasConcept C204232928 @default.
• W2078887787 hasConcept C204787440 @default.
• W2078887787 hasConcept C2776164576 @default.
• W2078887787 hasConcept C2776268809 @default.
• W2078887787 hasConcept C2776914184 @default.
• W2078887787 hasConcept C2778232976 @default.
• W2078887787 hasConcept C2780550940 @default.
• W2078887787 hasConcept C2780942790 @default.
• W2078887787 hasConcept C2781013607 @default.
• W2078887787 hasConcept C2781156865 @default.
• W2078887787 hasConcept C3020332539 @default.
• W2078887787 hasConcept C4224716 @default.
• W2078887787 hasConcept C55493867 @default.
• W2078887787 hasConcept C71924100 @default.
• W2078887787 hasConceptScore W2078887787C105702510 @default.
• W2078887787 hasConceptScore W2078887787C125870589 @default.
• W2078887787 hasConceptScore W2078887787C126322002 @default.
• W2078887787 hasConceptScore W2078887787C131075544 @default.
• W2078887787 hasConceptScore W2078887787C134018914 @default.
• W2078887787 hasConceptScore W2078887787C142724271 @default.
• W2078887787 hasConceptScore W2078887787C160160445 @default.
• W2078887787 hasConceptScore W2078887787C164027704 @default.
• W2078887787 hasConceptScore W2078887787C181199279 @default.
• W2078887787 hasConceptScore W2078887787C185592680 @default.

• next