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- W2078889696 abstract "Renin release and renin-substrate reaction in the isolated perfused rabbit kidney. Isolated rabbit kidneys were perfused in a closed-circuit system at constant pressure with a medium consisting of Tyrode's solution which contained 2% or 4% purified bovine albumin and a 40% suspension of washed rabbit erythrocytes. The perfusion medium was free from renin substrate (angiotensinogen). Addition of angiotensinogen to the perfusion medium induced a dose-dependent increase in renal vascular resistance within two to four min, whereas addition of albumin had no effect. During the first 45 min of perfusion, renin concentration in the perfusate rose slightly. Reduction of the perfusion pressure by 40 mmHg resulted in a steep increase in renin concentration in the perfusate. At the end of the perfusion period, renin content of the kidneys perfused at constant pressure was significantly higher than that of non-perfused control kidneys, whereas this increase in renin content was not seen in four of six kidneys in which perfusion pressure had been reduced during the perfusion period. Perfusion of the isolated kidney with an angiotensinogen-free medium is a useful method for studying the release of renin. Under these conditions the function of the isolated kidney can be maintained over prolonged periods without the interference of endogenously released angiotensin." @default.
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- W2078889696 date "1972-07-01" @default.
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- W2078889696 title "Renin release and renin-substrate reaction in the isolated perfused rabbit kidney" @default.
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- W2078889696 doi "https://doi.org/10.1038/ki.1972.63" @default.
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