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• W2078895122 abstract "A second ligand for colony-stimulating factor-1 receptor (CSF-1R) with distinct biologic activities had long been implicated but not appreciated until the recent discovery of interleukin (IL)-34. IL-34 and CSF-1 signal through this common receptor to mediate the biology of mononuclear phagocytic cells. Aberrant macrophage activation by CSF-1 and/or IL-34 is associated with numerous diseases, and clinical therapies targeting this pathway are being tested. Although IL-34 and CSF-1 have distinct activities under physiologic conditions, they appear functionally redundant in various disease states. Thus, blocking the activity of both might be necessary for maximal efficacy." @default.
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• W2078895122 date "2014-08-01" @default.
• W2078895122 modified "2023-10-16" @default.
• W2078895122 title "Targeting IL-34 in chronic inflammation" @default.
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• W2078895122 doi "https://doi.org/10.1016/j.drudis.2014.05.016" @default.
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