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• W2078901851 abstract "In Brief Background. In partial liver transplant, a reduction in the intrahepatic vascular bed produces a rise in the portal vein flow and the portal venous pressure gradient, leading to endothelial and, thereby, hepatocellular injury and death in a process known as “small-for-size” (SFS) syndrome. Objective. To demonstrate that a calibrated portocaval shunt prevents superfluous inflow in a porcine model of SFS transplant. Methods. Donor pigs (15–20 kg) underwent 70% hepatectomy. In 2 groups, a 6 mm (S6) (n = 6) or 12 mm (S12) (n = 6) Gore-Tex shunt was placed between the portal vein and infrahepatic inferior vena cava. In a third group, no portocaval shunt was placed (SFS) (n = 17). Grafts were stored for 5 hours at 4°C and then transplanted into recipients (30–35 kg). Results. Five-day survival was 29% in SFS, 100% in S6, and 0 in S12. Postreperfusion portal vein flow was 4-, 2-, and 1-times flow at baseline in SFS, S6, and S12, respectively. With respect to portal venous pressure gradient, both the 6- and 12-mm shunts effectively decompressed the portal bed. Aspartate aminotransferase and bilirubin rose and the Quick prothrombin time fell in all animals after reperfusion but improved significantly by day 5 in S6. Serum levels of endothelin-1 remained elevated in SFS and S12 but returned to baseline by 12 hours in S6: 2.76 (2.05–4.08) and 2.04 (1.97–2.12) versus 0.43 (0.26–0.50) pg/mL, respectively (P < 0.05 for both comparisons). Conclusions. A calibrated portocaval shunt that maintains portal vein flow about twice its baseline value produces a favorable outcome after SFS liver transplantation, avoiding endothelial injury due to portal hyperperfusion or to hypoperfusion because of excess shunting. In “small-for-size” (SFS) liver transplant, portal vein flow increases approximately four-fold over baseline and causes significant stress in the hepatic sinusoid. In this porcine model of SFS liver transplant, a calibrated portocaval shunt was created to prevent the deleterious consequences of this portal hyperperfusion. Shunts that maintained PVF around twice baseline protected the sinusoidal endothelium and resulted in 100% survival at five days." @default.
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• W2078901851 date "2011-06-01" @default.
• W2078901851 modified "2023-10-18" @default.
• W2078901851 title "Decompression of the Portal Bed and Twice-Baseline Portal Inflow Are Necessary for the Functional Recovery of a “Small-for-Size” Graft" @default.
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• W2078901851 doi "https://doi.org/10.1097/sla.0b013e3181ffb2d7" @default.
• W2078901851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21587116" @default.
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