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- W2078902011 abstract "1 Isoprenaline (non-selective) and noradrenaline (β1-selective) concentration-dependently relaxed ovine tracheal strips precontracted with carbachol. The pD2 values were 7.07 ± 0.08 and 6.13 ± 0.10 for isoprenaline and noradrenaline, respectively. In the same preparation, salbutamol either produced weak relaxation or in some cases, contractile responses indicating the presence of very little or no β2-adrenoceptors in this preparation. 2 Isoprenaline-and noradrenaline-induced relaxations were antagonized by propranolol and atenolol with pA2 values in the range reported in the literature for an action on β1-adrenoceptors. ICI 118551 also antagonized isoprenaline- and noradrenaline-induced relaxation but at concentrations much higher than are required to block β2-adrenoceptors, confirming that β2-adrenoceptors do not contribute significantly to these responses. 3 The selective β3-adrenoceptor agonist, BRL 37344A produced concentration-dependent relaxation of tracheal strips. BRL 37344A was a full agonist producing 100% relaxation of carbachol-induced tone. BRL 37344A-induced relaxation was weakly antagonized by propranolol confirming an action, mainly, on β3-adrenoceptors. Cyanopindolol antagonized isoprenaline-induced relaxation (in the presence of propranolol, 10−−7 m) with a pA2 value of 8.06 ± 0.24. 4 It was therefore concluded that β1- and β3-adrenoceptors mediated agonist-induced relaxation in sheep tracheal strips." @default.
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- W2078902011 date "1999-08-01" @default.
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- W2078902011 title "beta1- and beta3-adrenoceptors mediate relaxation in ovine trachealis smooth muscle" @default.
- W2078902011 doi "https://doi.org/10.1046/j.1365-2680.1999.00134.x" @default.
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