Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078902355> ?p ?o ?g. }
- W2078902355 endingPage "384" @default.
- W2078902355 startingPage "355" @default.
- W2078902355 abstract "A large number of highly selective GABAA and, more recently, GABAB receptor ligands have been developed and used for receptor characterization. Whereas full agonists and antagonists at GABAA receptors, for different reasons, may be difficult to use therapeutically, partial GABAA agonists may have therapeutic interest. The efficacious partial GABAA agonist, THIP, shows analgesic and anxiolytic effects in man, but THIP is ineffective as an antiepileptic agent, and PET studies have disclosed that THIP increases glucose metabolism in epileptic patients and human volunteers. In principle, GABAA antagonists may be used therapeutically in Alzheimer's disease and schizophrenia, but low-efficacy partial GABAA agonists may have particular interest in these disorders. Using the nonannulated THIP analogue, 4-PIOL, as a lead, a series of partial GABAA agonists showing a broad spectrum of relative efficacies have been developed." @default.
- W2078902355 created "2016-06-24" @default.
- W2078902355 creator A5005937010 @default.
- W2078902355 creator A5021253711 @default.
- W2078902355 creator A5027458594 @default.
- W2078902355 creator A5043236966 @default.
- W2078902355 creator A5049222147 @default.
- W2078902355 date "1997-11-01" @default.
- W2078902355 modified "2023-09-26" @default.
- W2078902355 title "GABAA and GABAB receptor agonists, partial agonists, antagonists and modulators: design and therapeutic prospects" @default.
- W2078902355 cites W1037499252 @default.
- W2078902355 cites W1165624423 @default.
- W2078902355 cites W1514573559 @default.
- W2078902355 cites W1559269452 @default.
- W2078902355 cites W1565551672 @default.
- W2078902355 cites W1568213552 @default.
- W2078902355 cites W1577822422 @default.
- W2078902355 cites W1790275871 @default.
- W2078902355 cites W1877334982 @default.
- W2078902355 cites W1908131908 @default.
- W2078902355 cites W1937675039 @default.
- W2078902355 cites W1939037149 @default.
- W2078902355 cites W1963846290 @default.
- W2078902355 cites W1964760100 @default.
- W2078902355 cites W1965666249 @default.
- W2078902355 cites W1966837740 @default.
- W2078902355 cites W1967810931 @default.
- W2078902355 cites W1968420491 @default.
- W2078902355 cites W1969646120 @default.
- W2078902355 cites W1969683921 @default.
- W2078902355 cites W1973166376 @default.
- W2078902355 cites W1974491482 @default.
- W2078902355 cites W1975943077 @default.
- W2078902355 cites W1976581211 @default.
- W2078902355 cites W1978342290 @default.
- W2078902355 cites W1979422259 @default.
- W2078902355 cites W1985637710 @default.
- W2078902355 cites W1986619553 @default.
- W2078902355 cites W1988172266 @default.
- W2078902355 cites W1988704090 @default.
- W2078902355 cites W1989836507 @default.
- W2078902355 cites W1991871283 @default.
- W2078902355 cites W1992662107 @default.
- W2078902355 cites W1992792117 @default.
- W2078902355 cites W1993734202 @default.
- W2078902355 cites W1994261508 @default.
- W2078902355 cites W1994288348 @default.
- W2078902355 cites W1994472391 @default.
- W2078902355 cites W1994831700 @default.
- W2078902355 cites W1996486666 @default.
- W2078902355 cites W1996902892 @default.
- W2078902355 cites W1997413098 @default.
- W2078902355 cites W1997752107 @default.
- W2078902355 cites W1997967494 @default.
- W2078902355 cites W1998407973 @default.
- W2078902355 cites W2007580188 @default.
- W2078902355 cites W2007911341 @default.
- W2078902355 cites W2007929414 @default.
- W2078902355 cites W2008553169 @default.
- W2078902355 cites W2008621323 @default.
- W2078902355 cites W2009415563 @default.
- W2078902355 cites W2009828532 @default.
- W2078902355 cites W2011658568 @default.
- W2078902355 cites W2013253007 @default.
- W2078902355 cites W2014635182 @default.
- W2078902355 cites W2014774246 @default.
- W2078902355 cites W2015077338 @default.
- W2078902355 cites W2015289041 @default.
- W2078902355 cites W2015508129 @default.
- W2078902355 cites W2018746730 @default.
- W2078902355 cites W2019409824 @default.
- W2078902355 cites W2021637002 @default.
- W2078902355 cites W2023468172 @default.
- W2078902355 cites W2023469110 @default.
- W2078902355 cites W2023546249 @default.
- W2078902355 cites W2026308613 @default.
- W2078902355 cites W2026559607 @default.
- W2078902355 cites W2027646804 @default.
- W2078902355 cites W2029559333 @default.
- W2078902355 cites W2031745952 @default.
- W2078902355 cites W2032630689 @default.
- W2078902355 cites W2033281125 @default.
- W2078902355 cites W2033874647 @default.
- W2078902355 cites W2033918721 @default.
- W2078902355 cites W2036135297 @default.
- W2078902355 cites W2038768614 @default.
- W2078902355 cites W2039789476 @default.
- W2078902355 cites W2040742860 @default.
- W2078902355 cites W2041002238 @default.
- W2078902355 cites W2041222943 @default.
- W2078902355 cites W2042232934 @default.
- W2078902355 cites W2042235627 @default.
- W2078902355 cites W2042645082 @default.
- W2078902355 cites W2043763965 @default.
- W2078902355 cites W2045976382 @default.
- W2078902355 cites W2048452263 @default.
- W2078902355 cites W2050089594 @default.
- W2078902355 cites W2050122750 @default.