FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078902544> ?p ?o ?g. }

• W2078902544 endingPage "291" @default.
• W2078902544 startingPage "285" @default.
• W2078902544 abstract "D-Tagatose (D-tag), a hexose bulk sweetener, does not affect plasma glucose levels when orally administered to rodents. Additionally, D-tag attenuates the rise in plasma glucose after mice are administered oral sucrose. The current study was undertaken to investigate the acute glycaemic effects of oral D-tag alone or in combination with oral glucose in human subjects with and without type 2 diabetes mellitus. Glycaemic responses to D-tag also were investigated in subjects after oral sucrose to examine whether the glucose-lowering effects of D-tag in rodents may result from a direct inhibition of intestinal disaccharidases.Eight normal and eight subjects with diabetes mellitus were administered 75 g of glucose, 75 g of D-tag, or 75 g of D-tag 30 min prior to a 75 g oral glucose tolerance test (OGTT). Five patients with diabetes mellitus were challenged with a 75 g oral sucrose tolerance test (OSTT) with and without oral pre-treatment with 75 g of D-tag. Patients with diabetes mellitus also received separate 0, 10, 15, 20 and 30 g of D-tag 30 min prior to a 75 g OGTT.Oral loading with D-tag alone led to no changes in glucose or insulin levels in either normal patients or those with diabetes mellitus. Pre-OGTT treatment with 75 g D-tag, however, attenuated the rise in glucose levels in patients with diabetes mellitus (p < 0.02 at 60 and 180 min, and p < 0.01 at 120 min). The glucose area under the curve (AUC) was reduced significantly also by pre-treatment with D-tag in a dose-dependent manner in patients with diabetes mellitus (p < 0.05 for 10 g D-tag, p < 0.001 for 20 g D-tag, and p = 0.0001 for 30 g D-tag). In patients with diabetes mellitus 75 g D-tag similarly attenuated the rise in glucose following an OSTT (p < 0.01 at 30 min, and p < 0.02 at 60 min). Pre-treatment with 75 g D-tag also tended to blunt the rise in insulin following an OGTT in normal patients (p = 0.07 for insulin AUC) but not patients with diabetes mellitus (p = 0.66). Following 75 g of oral D-tag in four normal patients, plasma D-tag levels rose to a mean peak level of 3.6 mg/dl at 90 min. The administration of 75 g D-tag led to diarrhoea, nausea and/or flatulence in 100% of subjects. When D-tag was administered at lower doses ranging from 10 g to 30 g, only three of 10 patients with diabetes mellitus had gastrointestinal symptoms which were much more mild than those evoked by 75 g D-tag.These results show that oral D-tag significantly blunts the rise in plasma glucose seen after oral glucose in patients with diabetes mellitus in a dose-dependent manner without significantly affecting insulin levels. The minimal elevation of plasma D-tag levels in normal patients and the adverse gastrointestinal effects seen following larger doses of D-tag support poor absorption of this hexose and suggest that D-tag may act by attenuating glucose absorption in the intestine. D-tag may be a useful therapeutic adjunct in the management of type 2 diabetes mellitus." @default.
• W2078902544 created "2016-06-24" @default.
• W2078902544 creator A5021274038 @default.
• W2078902544 creator A5074233628 @default.
• W2078902544 creator A5087798533 @default.
• W2078902544 date "1999-09-01" @default.
• W2078902544 modified "2023-10-14" @default.
• W2078902544 title "D-tagatose, a novel hexose: acute effects on carbohydrate tolerance in subjects with and without type 2 diabetes" @default.
• W2078902544 cites W1883134439 @default.
• W2078902544 cites W1903030876 @default.
• W2078902544 cites W1967592303 @default.
• W2078902544 cites W1980062765 @default.
• W2078902544 cites W1980932964 @default.
• W2078902544 cites W2005208228 @default.
• W2078902544 cites W2018001558 @default.
• W2078902544 cites W2022869754 @default.
• W2078902544 cites W2031426031 @default.
• W2078902544 cites W2049020736 @default.
• W2078902544 cites W2068372129 @default.
• W2078902544 cites W2076641670 @default.
• W2078902544 cites W2078089300 @default.
• W2078902544 cites W2081375366 @default.
• W2078902544 cites W2088910012 @default.
• W2078902544 cites W2090098929 @default.
• W2078902544 cites W2133220233 @default.
• W2078902544 cites W2163213453 @default.
• W2078902544 cites W2326712698 @default.
• W2078902544 cites W2769264260 @default.
• W2078902544 cites W4242088026 @default.
• W2078902544 cites W4247237039 @default.
• W2078902544 cites W4248142985 @default.
• W2078902544 doi "https://doi.org/10.1046/j.1463-1326.1999.00039.x" @default.
• W2078902544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11225640" @default.
• W2078902544 hasPublicationYear "1999" @default.
• W2078902544 type Work @default.
• W2078902544 sameAs 2078902544 @default.
• W2078902544 citedByCount "108" @default.
• W2078902544 countsByYear W20789025442012 @default.
• W2078902544 countsByYear W20789025442013 @default.
• W2078902544 countsByYear W20789025442014 @default.
• W2078902544 countsByYear W20789025442015 @default.
• W2078902544 countsByYear W20789025442016 @default.
• W2078902544 countsByYear W20789025442017 @default.
• W2078902544 countsByYear W20789025442018 @default.
• W2078902544 countsByYear W20789025442019 @default.
• W2078902544 countsByYear W20789025442020 @default.
• W2078902544 countsByYear W20789025442021 @default.
• W2078902544 countsByYear W20789025442022 @default.
• W2078902544 countsByYear W20789025442023 @default.
• W2078902544 crossrefType "journal-article" @default.
• W2078902544 hasAuthorship W2078902544A5021274038 @default.
• W2078902544 hasAuthorship W2078902544A5074233628 @default.
• W2078902544 hasAuthorship W2078902544A5087798533 @default.
• W2078902544 hasConcept C126322002 @default.
• W2078902544 hasConcept C134018914 @default.
• W2078902544 hasConcept C17093226 @default.
• W2078902544 hasConcept C181199279 @default.
• W2078902544 hasConcept C185592680 @default.
• W2078902544 hasConcept C2776393687 @default.
• W2078902544 hasConcept C2777056448 @default.
• W2078902544 hasConcept C2777391703 @default.
• W2078902544 hasConcept C2778597767 @default.
• W2078902544 hasConcept C2778977261 @default.
• W2078902544 hasConcept C2779306644 @default.
• W2078902544 hasConcept C2780833929 @default.
• W2078902544 hasConcept C2910068830 @default.
• W2078902544 hasConcept C55493867 @default.
• W2078902544 hasConcept C555293320 @default.
• W2078902544 hasConcept C71924100 @default.
• W2078902544 hasConcept C76318530 @default.
• W2078902544 hasConceptScore W2078902544C126322002 @default.
• W2078902544 hasConceptScore W2078902544C134018914 @default.
• W2078902544 hasConceptScore W2078902544C17093226 @default.
• W2078902544 hasConceptScore W2078902544C181199279 @default.
• W2078902544 hasConceptScore W2078902544C185592680 @default.
• W2078902544 hasConceptScore W2078902544C2776393687 @default.
• W2078902544 hasConceptScore W2078902544C2777056448 @default.
• W2078902544 hasConceptScore W2078902544C2777391703 @default.
• W2078902544 hasConceptScore W2078902544C2778597767 @default.
• W2078902544 hasConceptScore W2078902544C2778977261 @default.
• W2078902544 hasConceptScore W2078902544C2779306644 @default.
• W2078902544 hasConceptScore W2078902544C2780833929 @default.
• W2078902544 hasConceptScore W2078902544C2910068830 @default.
• W2078902544 hasConceptScore W2078902544C55493867 @default.
• W2078902544 hasConceptScore W2078902544C555293320 @default.
• W2078902544 hasConceptScore W2078902544C71924100 @default.
• W2078902544 hasConceptScore W2078902544C76318530 @default.
• W2078902544 hasIssue "5" @default.
• W2078902544 hasLocation W20789025441 @default.
• W2078902544 hasLocation W20789025442 @default.
• W2078902544 hasOpenAccess W2078902544 @default.
• W2078902544 hasPrimaryLocation W20789025441 @default.
• W2078902544 hasRelatedWork W1516011116 @default.
• W2078902544 hasRelatedWork W1979422211 @default.
• W2078902544 hasRelatedWork W1981260910 @default.
• W2078902544 hasRelatedWork W2125143421 @default.
• W2078902544 hasRelatedWork W2146570278 @default.
• W2078902544 hasRelatedWork W2161872195 @default.

• next