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- W2078902729 abstract "In previous studies, we have shown that DMSO reduces proteinuria in passive Heymann nephritis (PHN). We have now extended these studies to include the use of colchicine (C), a known inhibitor of microtubule function. In addition, colchicine alters the shape of glomerular epithelial cells. Rats were treated with saline (controls) or C (0.05 mg/kg/d i.p. × 28 days). Controls excreted 105 ± 22 and C-treated rats, 37 ± 6 mg/d, p <0.05. Onset of treatment during the autologous phase did not reduce proteinuria. Concomittant treatment with indomethacin abolished the beneficial effect of C. Whereas low doses of DMSO alone, and C alone reduced proteinuria, a combination of the same doses of C plus DMSO provided no added advantage over each alone. These studies demonstrate that C and DMSO can reduce proteinuria in PHN possibly via a common mechanism. We have thus identified two probes which may be useful in studying the pathogenesis of proteinuria in this model." @default.
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- W2078902729 date "1984-04-01" @default.
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- W2078902729 title "COLCHICINE AND DMSO AS PROBES FOR STUDYING PROTEINURIA IN PASSIVE HEYMANN NEPHRITIS" @default.
- W2078902729 doi "https://doi.org/10.1203/00006450-198404001-01636" @default.
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