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- W2078902750 abstract "It is generally believed that apoptosis is not associated with inflammation. To explore the possibility that the interaction of phagocytes with apoptotic cells provides a negative or null signal for inflammation, we examined the cytokine production by thioglycollate-induced peritoneal exudate cells (PEC) upon interaction with a murine T cell clone (CTLL-2) cultured in the absence of interleukin-2 (IL-2). Coculturing of PEC with apoptotic CTLL-2 cells led to the production of not only anti-inflammatory cytokines but also pro-inflammatory ones, notably MIP-2, at the mRNA level, and neutrophils were accumulatedin vivoin response to the culture supernatant. Our findings suggest the possibility that apoptosis may be associated with leukocyte infiltrationin vivoin some situations." @default.
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- W2078902750 date "1997-10-01" @default.
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- W2078902750 title "Interaction of Phagocytes with Apoptotic Cells Leads to Production of Pro-inflammatory Cytokines" @default.
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- W2078902750 doi "https://doi.org/10.1006/bbrc.1997.7556" @default.
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