Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078903586> ?p ?o ?g. }
- W2078903586 endingPage "62" @default.
- W2078903586 startingPage "53" @default.
- W2078903586 abstract "TDP-43 is a nuclear protein whose abnormal aggregates are implicated in ALS and FTLD. Recently, an Asn/Gln rich C-terminal segment of TDP-43 has been shown to produce aggregation in vitro and reproduce most of the protein's pathological hallmarks in cells, but little is known about this segment's structure. Here, CD and 2D heteronuclear NMR spectroscopies provide evidence that peptides corresponding to the wild type and mutated sequences of this segment adopt chiefly disordered conformations that, in the case of the wild type sequence, spontaneously forms a β-sheet rich oligomer. Moreover, MD simulation provides evidence for a structure consisting of two β-strands and a well-defined, yet non-canonical structural element. Furthermore, MD simulations of four pathological mutations (Q343R, N345K, G348V and N352S) occurring in this segment predict that all of them could affect this region's structure. In particular, the Q343R variant tends to stabilize disordered conformers, N345K permits the formation of longer, more stable β-strands, and G348V tends to shorten and destabilize them. Finally, N352S acts to alter the β-stand register and when S352 is phosphorylated, it induces partial unfolding. Our results provide a better understanding of TDP-43 aggregation process and will be useful to design effectors capable to modulate its progression." @default.
- W2078903586 created "2016-06-24" @default.
- W2078903586 creator A5006206320 @default.
- W2078903586 creator A5017943087 @default.
- W2078903586 creator A5029821144 @default.
- W2078903586 creator A5030858191 @default.
- W2078903586 creator A5032436476 @default.
- W2078903586 creator A5042658190 @default.
- W2078903586 creator A5088910380 @default.
- W2078903586 date "2014-03-01" @default.
- W2078903586 modified "2023-10-18" @default.
- W2078903586 title "“Structural characterization of the minimal segment of TDP-43 competent for aggregation”" @default.
- W2078903586 cites W1522735924 @default.
- W2078903586 cites W1848433338 @default.
- W2078903586 cites W1929407592 @default.
- W2078903586 cites W1965647277 @default.
- W2078903586 cites W1967932847 @default.
- W2078903586 cites W1968726059 @default.
- W2078903586 cites W1976487792 @default.
- W2078903586 cites W1984308849 @default.
- W2078903586 cites W1984538960 @default.
- W2078903586 cites W198782672 @default.
- W2078903586 cites W1991208268 @default.
- W2078903586 cites W1994524751 @default.
- W2078903586 cites W2003618511 @default.
- W2078903586 cites W2004405255 @default.
- W2078903586 cites W2031292508 @default.
- W2078903586 cites W2031964319 @default.
- W2078903586 cites W2036024572 @default.
- W2078903586 cites W2037027251 @default.
- W2078903586 cites W2039361444 @default.
- W2078903586 cites W2050868331 @default.
- W2078903586 cites W2060211017 @default.
- W2078903586 cites W2061690801 @default.
- W2078903586 cites W2064367582 @default.
- W2078903586 cites W2065516118 @default.
- W2078903586 cites W2069171272 @default.
- W2078903586 cites W2076363659 @default.
- W2078903586 cites W2077216735 @default.
- W2078903586 cites W2080620346 @default.
- W2078903586 cites W2081420723 @default.
- W2078903586 cites W2084578579 @default.
- W2078903586 cites W2096324068 @default.
- W2078903586 cites W2112418305 @default.
- W2078903586 cites W2132121416 @default.
- W2078903586 cites W2132430755 @default.
- W2078903586 cites W2138906088 @default.
- W2078903586 cites W2150766477 @default.
- W2078903586 cites W2156454183 @default.
- W2078903586 cites W2157450464 @default.
- W2078903586 cites W2160311330 @default.
- W2078903586 cites W2160544821 @default.
- W2078903586 cites W2161605421 @default.
- W2078903586 cites W2170253382 @default.
- W2078903586 cites W4242009576 @default.
- W2078903586 doi "https://doi.org/10.1016/j.abb.2014.01.007" @default.
- W2078903586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24440310" @default.
- W2078903586 hasPublicationYear "2014" @default.
- W2078903586 type Work @default.
- W2078903586 sameAs 2078903586 @default.
- W2078903586 citedByCount "65" @default.
- W2078903586 countsByYear W20789035862014 @default.
- W2078903586 countsByYear W20789035862015 @default.
- W2078903586 countsByYear W20789035862016 @default.
- W2078903586 countsByYear W20789035862017 @default.
- W2078903586 countsByYear W20789035862018 @default.
- W2078903586 countsByYear W20789035862019 @default.
- W2078903586 countsByYear W20789035862020 @default.
- W2078903586 countsByYear W20789035862021 @default.
- W2078903586 countsByYear W20789035862022 @default.
- W2078903586 countsByYear W20789035862023 @default.
- W2078903586 crossrefType "journal-article" @default.
- W2078903586 hasAuthorship W2078903586A5006206320 @default.
- W2078903586 hasAuthorship W2078903586A5017943087 @default.
- W2078903586 hasAuthorship W2078903586A5029821144 @default.
- W2078903586 hasAuthorship W2078903586A5030858191 @default.
- W2078903586 hasAuthorship W2078903586A5032436476 @default.
- W2078903586 hasAuthorship W2078903586A5042658190 @default.
- W2078903586 hasAuthorship W2078903586A5088910380 @default.
- W2078903586 hasConcept C104317684 @default.
- W2078903586 hasConcept C12554922 @default.
- W2078903586 hasConcept C143065580 @default.
- W2078903586 hasConcept C178790620 @default.
- W2078903586 hasConcept C185592680 @default.
- W2078903586 hasConcept C18705241 @default.
- W2078903586 hasConcept C202751555 @default.
- W2078903586 hasConcept C27523624 @default.
- W2078903586 hasConcept C2778112365 @default.
- W2078903586 hasConcept C2780642029 @default.
- W2078903586 hasConcept C32909587 @default.
- W2078903586 hasConcept C47701112 @default.
- W2078903586 hasConcept C51785407 @default.
- W2078903586 hasConcept C55493867 @default.
- W2078903586 hasConcept C66974803 @default.
- W2078903586 hasConcept C71240020 @default.
- W2078903586 hasConcept C8010536 @default.
- W2078903586 hasConcept C86803240 @default.
- W2078903586 hasConcept C92381491 @default.