Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078903971> ?p ?o ?g. }
- W2078903971 endingPage "7771" @default.
- W2078903971 startingPage "7767" @default.
- W2078903971 abstract "High-resolution crystal structures are described for carboxypeptidase A (EC 3.4.17.1) in crystals grown at pH 8.5, 9.0, and 9.5 and compared with the structure at pH 7.5. The comparison shows that in the pH range of 7.5-9.5 the enzyme structure is practically unchanged, and, most importantly, that the flexible side chain of Tyr-248 remains exclusively in the up position, away from the Zn atom, throughout the pH range. There is no evidence for binding of Tyr-248 to Zn at any of these pH values. We conclude that the interaction of Tyr-248 with Zn is not an essential part of the mechanism of carboxypeptidase A and that its occurrence is an artifact of chemical modification of Tyr-248. It is also suggested that Tyr-248 is not uniquely associated with the observed high pK of the enzymatic hydrolysis." @default.
- W2078903971 created "2016-06-24" @default.
- W2078903971 creator A5011337144 @default.
- W2078903971 creator A5021792279 @default.
- W2078903971 creator A5060946176 @default.
- W2078903971 date "1984-12-01" @default.
- W2078903971 modified "2023-09-27" @default.
- W2078903971 title "Effects of pH on the structure and function of carboxypeptidase A: crystallographic studies." @default.
- W2078903971 cites W1526775414 @default.
- W2078903971 cites W1532179928 @default.
- W2078903971 cites W1595669998 @default.
- W2078903971 cites W1620796 @default.
- W2078903971 cites W1914630957 @default.
- W2078903971 cites W1966721068 @default.
- W2078903971 cites W1968395904 @default.
- W2078903971 cites W1968929239 @default.
- W2078903971 cites W1971679585 @default.
- W2078903971 cites W1972499170 @default.
- W2078903971 cites W1972894386 @default.
- W2078903971 cites W1976419226 @default.
- W2078903971 cites W1976424056 @default.
- W2078903971 cites W1977956827 @default.
- W2078903971 cites W1980404219 @default.
- W2078903971 cites W1987142003 @default.
- W2078903971 cites W1994556899 @default.
- W2078903971 cites W1995149923 @default.
- W2078903971 cites W1998102947 @default.
- W2078903971 cites W2009834336 @default.
- W2078903971 cites W2009995683 @default.
- W2078903971 cites W2012602453 @default.
- W2078903971 cites W2013304453 @default.
- W2078903971 cites W2015191038 @default.
- W2078903971 cites W2020087324 @default.
- W2078903971 cites W2021754494 @default.
- W2078903971 cites W2039388179 @default.
- W2078903971 cites W2049659492 @default.
- W2078903971 cites W2051858751 @default.
- W2078903971 cites W2058309196 @default.
- W2078903971 cites W2058594605 @default.
- W2078903971 cites W2061010116 @default.
- W2078903971 cites W2062932836 @default.
- W2078903971 cites W2070057462 @default.
- W2078903971 cites W2070516655 @default.
- W2078903971 cites W2075233351 @default.
- W2078903971 cites W2078887567 @default.
- W2078903971 cites W2083110994 @default.
- W2078903971 cites W2089555384 @default.
- W2078903971 cites W2091236199 @default.
- W2078903971 cites W2119594150 @default.
- W2078903971 cites W2177248785 @default.
- W2078903971 cites W2322884814 @default.
- W2078903971 cites W2328462807 @default.
- W2078903971 cites W2423478157 @default.
- W2078903971 cites W3148237160 @default.
- W2078903971 cites W99227613 @default.
- W2078903971 doi "https://doi.org/10.1073/pnas.81.24.7767" @default.
- W2078903971 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/392233" @default.
- W2078903971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6595659" @default.
- W2078903971 hasPublicationYear "1984" @default.
- W2078903971 type Work @default.
- W2078903971 sameAs 2078903971 @default.
- W2078903971 citedByCount "13" @default.
- W2078903971 crossrefType "journal-article" @default.
- W2078903971 hasAuthorship W2078903971A5011337144 @default.
- W2078903971 hasAuthorship W2078903971A5021792279 @default.
- W2078903971 hasAuthorship W2078903971A5060946176 @default.
- W2078903971 hasBestOaLocation W20789039711 @default.
- W2078903971 hasConcept C108477463 @default.
- W2078903971 hasConcept C115624301 @default.
- W2078903971 hasConcept C136398272 @default.
- W2078903971 hasConcept C181199279 @default.
- W2078903971 hasConcept C185592680 @default.
- W2078903971 hasConcept C2780120296 @default.
- W2078903971 hasConcept C41183919 @default.
- W2078903971 hasConcept C55493867 @default.
- W2078903971 hasConcept C71240020 @default.
- W2078903971 hasConcept C8010536 @default.
- W2078903971 hasConcept C94412978 @default.
- W2078903971 hasConceptScore W2078903971C108477463 @default.
- W2078903971 hasConceptScore W2078903971C115624301 @default.
- W2078903971 hasConceptScore W2078903971C136398272 @default.
- W2078903971 hasConceptScore W2078903971C181199279 @default.
- W2078903971 hasConceptScore W2078903971C185592680 @default.
- W2078903971 hasConceptScore W2078903971C2780120296 @default.
- W2078903971 hasConceptScore W2078903971C41183919 @default.
- W2078903971 hasConceptScore W2078903971C55493867 @default.
- W2078903971 hasConceptScore W2078903971C71240020 @default.
- W2078903971 hasConceptScore W2078903971C8010536 @default.
- W2078903971 hasConceptScore W2078903971C94412978 @default.
- W2078903971 hasIssue "24" @default.
- W2078903971 hasLocation W20789039711 @default.
- W2078903971 hasLocation W20789039712 @default.
- W2078903971 hasLocation W20789039713 @default.
- W2078903971 hasLocation W20789039714 @default.
- W2078903971 hasLocation W20789039715 @default.
- W2078903971 hasOpenAccess W2078903971 @default.
- W2078903971 hasPrimaryLocation W20789039711 @default.
- W2078903971 hasRelatedWork W1500944778 @default.