FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078904921> ?p ?o ?g. }

• W2078904921 endingPage "e29389" @default.
• W2078904921 startingPage "e29389" @default.
• W2078904921 abstract "Leptin improves insulin sensitivity in skeletal muscle. Our goal was to determine whether proteins controlling GLUT4 traffic are altered by leptin deficiency and in vivo leptin administration in skeletal muscle of wild type and ob/ob mice. Leptin-deficient ob/ob mice were divided in three groups: control, leptin-treated (1 mg/kg/d) and leptin pair-fed ob/ob mice. Microarray analysis revealed that 1,546 and 1,127 genes were regulated by leptin deficiency and leptin treatment, respectively. Among these, we identified 24 genes involved in intracellular vesicle-mediated transport in ob/ob mice. TBC1 domain family, member 1 (Tbc1d1), a negative regulator of GLUT4 translocation, was up-regulated (P = 0.001) in ob/ob mice as compared to wild types. Importantly, leptin treatment reduced the transcript levels of Tbc1d1 (P<0.001) and Tbc1d4 (P = 0.004) in the leptin-treated ob/ob as compared to pair-fed ob/ob animals. In addition, phosphorylation levels of TBC1D1 and TBC1D4 were enhanced in leptin-treated ob/ob as compared to control ob/ob (P = 0.015 and P = 0.023, respectively) and pair-fed ob/ob (P = 0.036 and P = 0.034, respectively) mice. Despite similar GLUT4 protein expression in wild type and ob/ob groups a different immunolocalization of this protein was evidenced in muscle sections. Leptin treatment increased GLUT4 immunoreactivity in gastrocnemius and extensor digitorum longus sections of leptin-treated ob/ob mice. Moreover, GLUT4 protein detected in immunoprecipitates from TBC1D4 was reduced by leptin replacement compared to control ob/ob (P = 0.013) and pair-fed ob/ob (P = 0.037) mice. Our findings suggest that leptin enhances the intracellular GLUT4 transport in skeletal muscle of ob/ob animals by reducing the expression and activity of the negative regulators of GLUT4 traffic TBC1D1 and TBC1D4." @default.
• W2078904921 created "2016-06-24" @default.
• W2078904921 creator A5006385372 @default.
• W2078904921 creator A5007732990 @default.
• W2078904921 creator A5016527523 @default.
• W2078904921 creator A5027542066 @default.
• W2078904921 creator A5036389069 @default.
• W2078904921 creator A5044191909 @default.
• W2078904921 creator A5053231875 @default.
• W2078904921 creator A5062747317 @default.
• W2078904921 creator A5067550012 @default.
• W2078904921 date "2012-01-09" @default.
• W2078904921 modified "2023-10-12" @default.
• W2078904921 title "Leptin Reduces the Expression and Increases the Phosphorylation of the Negative Regulators of GLUT4 Traffic TBC1D1 and TBC1D4 in Muscle of ob/ob Mice" @default.
• W2078904921 cites W1580569338 @default.
• W2078904921 cites W1596136472 @default.
• W2078904921 cites W1788773694 @default.
• W2078904921 cites W1869018261 @default.
• W2078904921 cites W1964830835 @default.
• W2078904921 cites W1973630137 @default.
• W2078904921 cites W1976860473 @default.
• W2078904921 cites W1978777870 @default.
• W2078904921 cites W1980849907 @default.
• W2078904921 cites W1985381832 @default.
• W2078904921 cites W1987355039 @default.
• W2078904921 cites W1989829058 @default.
• W2078904921 cites W1994808039 @default.
• W2078904921 cites W1995353658 @default.
• W2078904921 cites W2002233417 @default.
• W2078904921 cites W2005753856 @default.
• W2078904921 cites W2010367429 @default.
• W2078904921 cites W2010763118 @default.
• W2078904921 cites W2012116123 @default.
• W2078904921 cites W2017414380 @default.
• W2078904921 cites W2021065679 @default.
• W2078904921 cites W2027909585 @default.
• W2078904921 cites W2029749539 @default.
• W2078904921 cites W2036024262 @default.
• W2078904921 cites W2036441405 @default.
• W2078904921 cites W2041608075 @default.
• W2078904921 cites W2042444876 @default.
• W2078904921 cites W2042917756 @default.
• W2078904921 cites W2046472576 @default.
• W2078904921 cites W2051702381 @default.
• W2078904921 cites W2054912558 @default.
• W2078904921 cites W2060109610 @default.
• W2078904921 cites W2062425773 @default.
• W2078904921 cites W2063958537 @default.
• W2078904921 cites W2066713996 @default.
• W2078904921 cites W2066932627 @default.
• W2078904921 cites W2076075378 @default.
• W2078904921 cites W2076823992 @default.
• W2078904921 cites W2077230920 @default.
• W2078904921 cites W2078374645 @default.
• W2078904921 cites W2084432666 @default.
• W2078904921 cites W2096012966 @default.
• W2078904921 cites W2096089065 @default.
• W2078904921 cites W2101715194 @default.
• W2078904921 cites W2108106499 @default.
• W2078904921 cites W2120909223 @default.
• W2078904921 cites W2121563931 @default.
• W2078904921 cites W2123013611 @default.
• W2078904921 cites W2124267724 @default.
• W2078904921 cites W2124956707 @default.
• W2078904921 cites W2125552035 @default.
• W2078904921 cites W2126875959 @default.
• W2078904921 cites W2131356526 @default.
• W2078904921 cites W2133383405 @default.
• W2078904921 cites W2133460318 @default.
• W2078904921 cites W2142274602 @default.
• W2078904921 cites W2143449370 @default.
• W2078904921 cites W2147964952 @default.
• W2078904921 cites W2148321229 @default.
• W2078904921 cites W2148649414 @default.
• W2078904921 cites W2153446853 @default.
• W2078904921 cites W2154597181 @default.
• W2078904921 cites W2157226678 @default.
• W2078904921 cites W2161532807 @default.
• W2078904921 cites W2164134117 @default.
• W2078904921 cites W2167710863 @default.
• W2078904921 cites W2169358395 @default.
• W2078904921 cites W2170864435 @default.
• W2078904921 cites W2187579305 @default.
• W2078904921 cites W4205370185 @default.
• W2078904921 doi "https://doi.org/10.1371/journal.pone.0029389" @default.
• W2078904921 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3253781" @default.
• W2078904921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22253718" @default.
• W2078904921 hasPublicationYear "2012" @default.
• W2078904921 type Work @default.
• W2078904921 sameAs 2078904921 @default.
• W2078904921 citedByCount "25" @default.
• W2078904921 countsByYear W20789049212013 @default.
• W2078904921 countsByYear W20789049212014 @default.
• W2078904921 countsByYear W20789049212015 @default.
• W2078904921 countsByYear W20789049212016 @default.
• W2078904921 countsByYear W20789049212018 @default.
• W2078904921 countsByYear W20789049212019 @default.
• W2078904921 countsByYear W20789049212020 @default.

• next