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• W2078906823 abstract "The molecular mechanism underlying the retention of intron-containing mRNAs in the nucleus is not understood. Here, we show that retention of intron-containing mRNAs in yeast is mediated by perinuclearly located Mlp1. Deletion of MLP1 impairs retention while having no effect on mRNA splicing. The Mlp1-dependent leakage of intron-containing RNAs is increased in presence of ts-prp18 delta, a splicing mutant. When overall pre-mRNA levels are increased by deletion of RRP6, a nuclear exosome component, MLP1 deletion augments leakage of only the intron-containing portion of mRNAs. Our data suggest, moreover, that Mlp1-dependent retention is mediated via the 5' splice site. Intriguingly, we found Mlp-proteins to be present only on sections of the NE adjacent to chromatin. We propose that at this confined site the perinuclear Mlp1 implements a quality control step prior to export, physically retaining faulty pre-mRNAs." @default.
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• W2078906823 date "2004-01-01" @default.
• W2078906823 modified "2023-10-14" @default.
• W2078906823 title "Nuclear Retention of Unspliced mRNAs in Yeast Is Mediated by Perinuclear Mlp1" @default.
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• W2078906823 doi "https://doi.org/10.1016/s0092-8674(03)01026-2" @default.
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