FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078911091> ?p ?o ?g. }

• W2078911091 endingPage "217" @default.
• W2078911091 startingPage "211" @default.
• W2078911091 abstract "There has been an increasing interest in recent years in the role of stem cells. With an extensive understanding of their biology, a major role for stem cells in the malignant process has been proposed and the existence of cancer stem cells (CSCs) has been confirmed in hematopoietic malignancies and solid organ malignancies including brain cancer, breast, prostate, colon, and pancreatic cancer. Lung cancer is the leading cause of cancer mortality in most large cities of China. It is possible that lung cancer contains cancer stem cells responsible for its malignancy. The aim of this study is to identify, characterize and enrich the CSC population that drives and maintains lung adenocarcinoma growth and metastasis. Side population (SP) cell analysis and sorting were applied on human lung adenocarcinoma cell line and an attempt to further enrich them by preliminary serum-free culture before fluorescence activated cell sorting (FACS) was done. Stem cell properties of SP cells were evaluated by their proliferative index, colony-forming efficiency, tumorigenic potential, bi-differentiation capacity and the expression of common stem cell surface markers. Lung cancer cells could grow in a serum-free Medium (SFM) as non-adherent spheres similar to neurospheres or mammospheres. The proportion of SP cells in cell spheres was significantly higher than that in cells grown as monolayers. SP cells had a greater proliferative index, a higher colony-forming efficiency and a greater ability to form tumor in vivo. SP cells were both CCA positive and SP-C positive while non-SP cells were only SP-C positive. Flow cytometric analysis of cell phenotype showed that SP cells expressed CD133 and CD44, the common cell surface markers of cancer stem cells, while non-SP cells only expressed CD44. SP cells existed in human lung adenocarcinoma cell lines and they could be further enriched by preliminary serum-free culture before FACS sorting. SP cells possessed the properties of cancer stem cells." @default.
• W2078911091 created "2016-06-24" @default.
• W2078911091 creator A5002747739 @default.
• W2078911091 creator A5006811236 @default.
• W2078911091 creator A5040233081 @default.
• W2078911091 creator A5081900779 @default.
• W2078911091 date "2010-09-01" @default.
• W2078911091 modified "2023-09-27" @default.
• W2078911091 title "Identification and characterization of side population cells in human lung adenocarcinoma SPC-A1 cells" @default.
• W2078911091 cites W1483167997 @default.
• W2078911091 cites W2009886857 @default.
• W2078911091 cites W2013618744 @default.
• W2078911091 cites W2014460771 @default.
• W2078911091 cites W2023427658 @default.
• W2078911091 cites W2051055358 @default.
• W2078911091 cites W2055757796 @default.
• W2078911091 cites W2062069198 @default.
• W2078911091 cites W2062512555 @default.
• W2078911091 cites W2082436048 @default.
• W2078911091 cites W2084418175 @default.
• W2078911091 cites W2086149372 @default.
• W2078911091 cites W2097454127 @default.
• W2078911091 cites W2100723703 @default.
• W2078911091 cites W2122147062 @default.
• W2078911091 cites W2124078079 @default.
• W2078911091 cites W2127617517 @default.
• W2078911091 cites W2152149208 @default.
• W2078911091 cites W2153382986 @default.
• W2078911091 cites W2154244494 @default.
• W2078911091 cites W2169736343 @default.
• W2078911091 cites W2169752217 @default.
• W2078911091 doi "https://doi.org/10.1007/s11670-010-0211-8" @default.
• W2078911091 hasPublicationYear "2010" @default.
• W2078911091 type Work @default.
• W2078911091 sameAs 2078911091 @default.
• W2078911091 citedByCount "0" @default.
• W2078911091 crossrefType "journal-article" @default.
• W2078911091 hasAuthorship W2078911091A5002747739 @default.
• W2078911091 hasAuthorship W2078911091A5006811236 @default.
• W2078911091 hasAuthorship W2078911091A5040233081 @default.
• W2078911091 hasAuthorship W2078911091A5081900779 @default.
• W2078911091 hasConcept C109159458 @default.
• W2078911091 hasConcept C121608353 @default.
• W2078911091 hasConcept C126322002 @default.
• W2078911091 hasConcept C142724271 @default.
• W2078911091 hasConcept C1491633281 @default.
• W2078911091 hasConcept C203014093 @default.
• W2078911091 hasConcept C2776256026 @default.
• W2078911091 hasConcept C2778630268 @default.
• W2078911091 hasConcept C2779013556 @default.
• W2078911091 hasConcept C2780546549 @default.
• W2078911091 hasConcept C2780932548 @default.
• W2078911091 hasConcept C2781182431 @default.
• W2078911091 hasConcept C28328180 @default.
• W2078911091 hasConcept C2908647359 @default.
• W2078911091 hasConcept C502942594 @default.
• W2078911091 hasConcept C54355233 @default.
• W2078911091 hasConcept C553184892 @default.
• W2078911091 hasConcept C55427017 @default.
• W2078911091 hasConcept C71924100 @default.
• W2078911091 hasConcept C86803240 @default.
• W2078911091 hasConcept C95444343 @default.
• W2078911091 hasConcept C96232424 @default.
• W2078911091 hasConcept C99454951 @default.
• W2078911091 hasConceptScore W2078911091C109159458 @default.
• W2078911091 hasConceptScore W2078911091C121608353 @default.
• W2078911091 hasConceptScore W2078911091C126322002 @default.
• W2078911091 hasConceptScore W2078911091C142724271 @default.
• W2078911091 hasConceptScore W2078911091C1491633281 @default.
• W2078911091 hasConceptScore W2078911091C203014093 @default.
• W2078911091 hasConceptScore W2078911091C2776256026 @default.
• W2078911091 hasConceptScore W2078911091C2778630268 @default.
• W2078911091 hasConceptScore W2078911091C2779013556 @default.
• W2078911091 hasConceptScore W2078911091C2780546549 @default.
• W2078911091 hasConceptScore W2078911091C2780932548 @default.
• W2078911091 hasConceptScore W2078911091C2781182431 @default.
• W2078911091 hasConceptScore W2078911091C28328180 @default.
• W2078911091 hasConceptScore W2078911091C2908647359 @default.
• W2078911091 hasConceptScore W2078911091C502942594 @default.
• W2078911091 hasConceptScore W2078911091C54355233 @default.
• W2078911091 hasConceptScore W2078911091C553184892 @default.
• W2078911091 hasConceptScore W2078911091C55427017 @default.
• W2078911091 hasConceptScore W2078911091C71924100 @default.
• W2078911091 hasConceptScore W2078911091C86803240 @default.
• W2078911091 hasConceptScore W2078911091C95444343 @default.
• W2078911091 hasConceptScore W2078911091C96232424 @default.
• W2078911091 hasConceptScore W2078911091C99454951 @default.
• W2078911091 hasIssue "3" @default.
• W2078911091 hasLocation W20789110911 @default.
• W2078911091 hasOpenAccess W2078911091 @default.
• W2078911091 hasPrimaryLocation W20789110911 @default.
• W2078911091 hasRelatedWork W1538961437 @default.
• W2078911091 hasRelatedWork W1556108917 @default.
• W2078911091 hasRelatedWork W1990678923 @default.
• W2078911091 hasRelatedWork W2068445725 @default.
• W2078911091 hasRelatedWork W2138240309 @default.
• W2078911091 hasRelatedWork W2165646078 @default.
• W2078911091 hasRelatedWork W2343191660 @default.

• next