Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078911958> ?p ?o ?g. }
- W2078911958 endingPage "E28" @default.
- W2078911958 startingPage "E17" @default.
- W2078911958 abstract "O-linked beta-N-acetylglucosamine (O-GlcNAc) is a dynamic posttranslational modification that, analogous to phosphorylation, cycles on and off serine and/or threonine hydroxyl groups. Cycling of O-GlcNAc is regulated by the concerted actions of O-GlcNAc transferase and O-GlcNAcase. GlcNAcylation is a nutrient/stress-sensitive modification that regulates proteins involved in a wide array of biological processes, including transcription, signaling, and metabolism. GlcNAcylation is involved in the etiology of glucose toxicity and chronic hyperglycemia-induced insulin resistance, a major hallmark of type 2 diabetes. Several reports demonstrate a strong positive correlation between GlcNAcylation and the development of insulin resistance. However, recent studies suggest that inhibiting GlcNAcylation does not prevent hyperglycemia-induced insulin resistance, suggesting that other mechanisms must also be involved. To date, proteomic analyses have identified more than 600 GlcNAcylated proteins in diverse functional classes. However, O-GlcNAc sites have been mapped on only a small percentage (<15%) of these proteins, most of which were isolated from brain or spinal cord tissue and not from other metabolically relevant tissues. Mapping the sites of GlcNAcylation is not only necessary to elucidate the complex cross-talk between GlcNAcylation and phosphorylation but is also key to the design of site-specific mutational studies and necessary for the generation of site-specific antibodies, both of which will help further decipher O-GlcNAc's functional roles. Recent technical advances in O-GlcNAc site-mapping methods should now finally allow for a much-needed increase in site-specific analyses to address the functional significance of O-GlcNAc in insulin resistance and glucose toxicity as well as other major biological processes." @default.
- W2078911958 created "2016-06-24" @default.
- W2078911958 creator A5004145848 @default.
- W2078911958 creator A5043863262 @default.
- W2078911958 creator A5091486452 @default.
- W2078911958 date "2008-07-01" @default.
- W2078911958 modified "2023-09-29" @default.
- W2078911958 title "Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity" @default.
- W2078911958 cites W1516265214 @default.
- W2078911958 cites W1549772227 @default.
- W2078911958 cites W1568866400 @default.
- W2078911958 cites W1590732591 @default.
- W2078911958 cites W1601059079 @default.
- W2078911958 cites W1652316604 @default.
- W2078911958 cites W1711248712 @default.
- W2078911958 cites W187434054 @default.
- W2078911958 cites W1967558431 @default.
- W2078911958 cites W1968005873 @default.
- W2078911958 cites W1968813770 @default.
- W2078911958 cites W1969939865 @default.
- W2078911958 cites W1970979133 @default.
- W2078911958 cites W1973787989 @default.
- W2078911958 cites W1979095700 @default.
- W2078911958 cites W1981194148 @default.
- W2078911958 cites W1985251960 @default.
- W2078911958 cites W1986758311 @default.
- W2078911958 cites W1987963824 @default.
- W2078911958 cites W1989430502 @default.
- W2078911958 cites W1989846327 @default.
- W2078911958 cites W1990421089 @default.
- W2078911958 cites W1992901862 @default.
- W2078911958 cites W1996110302 @default.
- W2078911958 cites W1996156805 @default.
- W2078911958 cites W1996786134 @default.
- W2078911958 cites W1997087248 @default.
- W2078911958 cites W1999351520 @default.
- W2078911958 cites W1999683656 @default.
- W2078911958 cites W2003376195 @default.
- W2078911958 cites W2009324889 @default.
- W2078911958 cites W2012232758 @default.
- W2078911958 cites W2015923950 @default.
- W2078911958 cites W2016371676 @default.
- W2078911958 cites W2017614262 @default.
- W2078911958 cites W2018639404 @default.
- W2078911958 cites W2019885733 @default.
- W2078911958 cites W2022428368 @default.
- W2078911958 cites W2025748859 @default.
- W2078911958 cites W2030205108 @default.
- W2078911958 cites W2031087463 @default.
- W2078911958 cites W2031957765 @default.
- W2078911958 cites W2033608921 @default.
- W2078911958 cites W2035020831 @default.
- W2078911958 cites W2037526260 @default.
- W2078911958 cites W2038880025 @default.
- W2078911958 cites W2041967294 @default.
- W2078911958 cites W2044688375 @default.
- W2078911958 cites W2045025174 @default.
- W2078911958 cites W2047576013 @default.
- W2078911958 cites W2048212725 @default.
- W2078911958 cites W2048670619 @default.
- W2078911958 cites W2049020770 @default.
- W2078911958 cites W2051948190 @default.
- W2078911958 cites W2052135200 @default.
- W2078911958 cites W2054664745 @default.
- W2078911958 cites W2054722953 @default.
- W2078911958 cites W2058370904 @default.
- W2078911958 cites W2059901822 @default.
- W2078911958 cites W2060799932 @default.
- W2078911958 cites W2061092524 @default.
- W2078911958 cites W2062236151 @default.
- W2078911958 cites W2066290187 @default.
- W2078911958 cites W2067729127 @default.
- W2078911958 cites W2069052453 @default.
- W2078911958 cites W2070666853 @default.
- W2078911958 cites W2071198735 @default.
- W2078911958 cites W2074332237 @default.
- W2078911958 cites W2075367283 @default.
- W2078911958 cites W2075375055 @default.
- W2078911958 cites W2076430609 @default.
- W2078911958 cites W2077903723 @default.
- W2078911958 cites W2080565765 @default.
- W2078911958 cites W2082502030 @default.
- W2078911958 cites W2083510841 @default.
- W2078911958 cites W2083563185 @default.
- W2078911958 cites W2085677500 @default.
- W2078911958 cites W2089159427 @default.
- W2078911958 cites W2089266364 @default.
- W2078911958 cites W2089693526 @default.
- W2078911958 cites W2092961164 @default.
- W2078911958 cites W2093757839 @default.
- W2078911958 cites W2097757455 @default.
- W2078911958 cites W2098161092 @default.
- W2078911958 cites W2101298061 @default.
- W2078911958 cites W2103404438 @default.
- W2078911958 cites W2106371385 @default.
- W2078911958 cites W2107128359 @default.
- W2078911958 cites W2111154780 @default.
- W2078911958 cites W2118488166 @default.