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- W2078911982 abstract "The interactions of anticancer drugs with cell membranes are of primary importance for drug transport, accumulation and activity. However, these interactions are very difficult to investigate because of the complexity of biological membranes. Lipid model membranes have therefore been built to gain insight into the collective role of lipids in drug–membrane interactions. Membranes can act as a barrier for drug molecules, sequester them or conversely may allow them to freely diffuse, thereby modulating the accumulation of drugs into cells. Lipid membranes also affect the ability of the efflux pump Pgp to bind and efflux anticancer drugs from cells. On the other hand, anticancer drugs can alter the structure and properties of lipid membranes, which are expected to influence the functioning of embedded proteins. The relevance of lipid model membranes to assess interactions between anticancer drugs and biomembranes is evidenced." @default.
- W2078911982 created "2016-06-24" @default.
- W2078911982 creator A5078174247 @default.
- W2078911982 creator A5089243342 @default.
- W2078911982 date "2014-09-01" @default.
- W2078911982 modified "2023-09-25" @default.
- W2078911982 title "Interactions of anticancer drugs with biomembranes: What can we learn from model membranes?" @default.
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- W2078911982 doi "https://doi.org/10.1016/j.jconrel.2014.05.012" @default.
- W2078911982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24859379" @default.
- W2078911982 hasPublicationYear "2014" @default.
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