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• W2078919205 abstract "Abstract Experiments extending over several years have now been completed in which local control of mammary tumors in C3H mice was compared with acute skin reactions in other mice for a number of fractionated X-ray and fast neutron schedules. This paper presents the latest results, summarizes the previously published results, and discusses the pattern which has now emerged. Two types of fractionated treatment have been investigated: short overall times of up to 4 days and longer overall times of 9–18 days. The effectiveness of each schedule was estimated by comparing the local tumor control that could be achieved for a given skin reaction. In the short treatment schedules, the extent of tumor control was very variable, ranging from poor to good. It was critically dependent on fraction size and on the interval between fractions in a way that was consistent with reozygenation in the tumor bring the crucial factor. In the longer treatment schedules, fraction size and interval were not so critical end overall time was the governing factor; too long overall dam yielded poor results because proliferation in the tumor was faster then in skin. In the short, variable, type of treatment it was shown that poor results using X-rays could be improved, to about the same level as the best X-ray results, by using either the specific hypoxic-cell radiosensitizing drug Ro-07-0582 with X-rays, or by using cyclotron-produced fast neutrons. These observations support the concept of hypoxia and reoxygenation being the crucial factors in short treatment schedules." @default.
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• W2078919205 date "1976-07-01" @default.
• W2078919205 modified "2023-09-26" @default.
• W2078919205 title "Optimum fractionation of the C3H mouse mammary carcinoma using X-rays, the hypoxic-cell radiosensitizer Ro-07-0582, or fast neutrons" @default.
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• W2078919205 doi "https://doi.org/10.1016/0360-3016(76)90139-5" @default.
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