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• W2078919511 abstract "Type I interferons (IFNs) have been shown to be involved in many immune defence and inflammatory responses. We here show that IFN-beta plays an absolute essential role in the efficient induction of all type I IFNs after infection of primary embryonic as well as primary adult fibroblasts with Sendai virus. In contrast, after immortalization of such fibroblasts with SV40 large T antigen, IFN-alpha4 can be induced independently of IFN-beta. However, efficient secretion of type I IFNs even in immortalized fibroblasts is only found when the complete signalling loop is induced by IFN-beta." @default.
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• W2078919511 date "2005-09-01" @default.
• W2078919511 modified "2023-10-16" @default.
• W2078919511 title "Transformation of mouse fibroblasts alters the induction pattern of type I IFNs after virus infection" @default.
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• W2078919511 doi "https://doi.org/10.1016/j.bbrc.2005.07.124" @default.
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