FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078940131> ?p ?o ?g. }

• W2078940131 endingPage "2408" @default.
• W2078940131 startingPage "2401" @default.
• W2078940131 abstract "Reduced activated partial thromboplastin time (aPTT) is a risk marker for incident and recurrent venous thromboembolism (VTE). Genetic factors influencing aPTT are not well understood, especially in populations of non-European ancestry. The present study aimed to identify aPTT-related gene variants in both European Americans (EAs) and African Americans (AAs). We conducted a genetic association study for aPTT in 9719 EAs and 2799 AAs from the Atherosclerosis Risk in Communities (ARIC) study. Using the Candidate Gene Association Resource (CARe) consortium candidate gene array, the analyses were based on ∼50 000 SNPs in ∼2000 candidate genes. In EAs, the analyses identified a new independent association for aPTT in F5 (rs2239852, P-value = 1.9 × 10(-8)), which clusters with a coding variant rs6030 (P-value = 7.8 × 10(-7)). The remaining significant signals were located on F5, HRG, KNG1, F11, F12 and ABO and have been previously reported in EA populations. In AAs, significant signals were identified in KNG1, HRG, F12, ABO and VWF, with the leading variants in KNG1, HRG and F12 being the same as in the EAs; the significant variant in VWF (rs2229446, P-value = 1.2 × 10(-6)) was specific to the AA sample (minor allele frequency = 19% in AAs and 0.2% in EAs) and has not been previously reported. This is the first study to report aPTT-related genetic variants in AAs. Our findings in AAs demonstrate transferability of previously reported associations with KNG1, HRG and F12 in EAs. We also identified new associations at F5 in EAs and VWF in AAs that have not been previously reported for aPTT." @default.
• W2078940131 created "2016-06-24" @default.
• W2078940131 creator A5001639456 @default.
• W2078940131 creator A5022683360 @default.
• W2078940131 creator A5030947777 @default.
• W2078940131 creator A5044048476 @default.
• W2078940131 creator A5058258081 @default.
• W2078940131 creator A5063972278 @default.
• W2078940131 creator A5075061959 @default.
• W2078940131 date "2014-12-30" @default.
• W2078940131 modified "2023-10-11" @default.
• W2078940131 title "A genetic association study of activated partial thromboplastin time in European Americans and African Americans: the ARIC Study" @default.
• W2078940131 cites W1535834464 @default.
• W2078940131 cites W1618588028 @default.
• W2078940131 cites W1953169434 @default.
• W2078940131 cites W1969736058 @default.
• W2078940131 cites W1974256045 @default.
• W2078940131 cites W1979038608 @default.
• W2078940131 cites W1984775450 @default.
• W2078940131 cites W2008874438 @default.
• W2078940131 cites W2019727519 @default.
• W2078940131 cites W2023525998 @default.
• W2078940131 cites W2024087337 @default.
• W2078940131 cites W2038331836 @default.
• W2078940131 cites W2040084796 @default.
• W2078940131 cites W2040924139 @default.
• W2078940131 cites W2043434342 @default.
• W2078940131 cites W2052215470 @default.
• W2078940131 cites W2055063721 @default.
• W2078940131 cites W2055198158 @default.
• W2078940131 cites W2057050982 @default.
• W2078940131 cites W2057485733 @default.
• W2078940131 cites W2059145105 @default.
• W2078940131 cites W2061001265 @default.
• W2078940131 cites W2063071114 @default.
• W2078940131 cites W2073393434 @default.
• W2078940131 cites W2074032101 @default.
• W2078940131 cites W2074475417 @default.
• W2078940131 cites W2077119068 @default.
• W2078940131 cites W2087784005 @default.
• W2078940131 cites W2090080882 @default.
• W2078940131 cites W2092087640 @default.
• W2078940131 cites W2112848098 @default.
• W2078940131 cites W2123411711 @default.
• W2078940131 cites W2124979797 @default.
• W2078940131 cites W2129792561 @default.
• W2078940131 cites W2135336914 @default.
• W2078940131 cites W2137886330 @default.
• W2078940131 cites W2142802339 @default.
• W2078940131 cites W2153306700 @default.
• W2078940131 cites W2157752701 @default.
• W2078940131 cites W2161633633 @default.
• W2078940131 cites W2413374319 @default.
• W2078940131 cites W4242416368 @default.
• W2078940131 doi "https://doi.org/10.1093/hmg/ddu732" @default.
• W2078940131 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4375421" @default.
• W2078940131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25552651" @default.
• W2078940131 hasPublicationYear "2014" @default.
• W2078940131 type Work @default.
• W2078940131 sameAs 2078940131 @default.
• W2078940131 citedByCount "7" @default.
• W2078940131 countsByYear W20789401312016 @default.
• W2078940131 countsByYear W20789401312017 @default.
• W2078940131 countsByYear W20789401312018 @default.
• W2078940131 countsByYear W20789401312020 @default.
• W2078940131 countsByYear W20789401312021 @default.
• W2078940131 countsByYear W20789401312022 @default.
• W2078940131 crossrefType "journal-article" @default.
• W2078940131 hasAuthorship W2078940131A5001639456 @default.
• W2078940131 hasAuthorship W2078940131A5022683360 @default.
• W2078940131 hasAuthorship W2078940131A5030947777 @default.
• W2078940131 hasAuthorship W2078940131A5044048476 @default.
• W2078940131 hasAuthorship W2078940131A5058258081 @default.
• W2078940131 hasAuthorship W2078940131A5063972278 @default.
• W2078940131 hasAuthorship W2078940131A5075061959 @default.
• W2078940131 hasBestOaLocation W20789401311 @default.
• W2078940131 hasConcept C104317684 @default.
• W2078940131 hasConcept C106208931 @default.
• W2078940131 hasConcept C126322002 @default.
• W2078940131 hasConcept C135763542 @default.
• W2078940131 hasConcept C153209595 @default.
• W2078940131 hasConcept C157410074 @default.
• W2078940131 hasConcept C176080213 @default.
• W2078940131 hasConcept C186413461 @default.
• W2078940131 hasConcept C2778261982 @default.
• W2078940131 hasConcept C2778382381 @default.
• W2078940131 hasConcept C54355233 @default.
• W2078940131 hasConcept C69991583 @default.
• W2078940131 hasConcept C71924100 @default.
• W2078940131 hasConcept C86803240 @default.
• W2078940131 hasConceptScore W2078940131C104317684 @default.
• W2078940131 hasConceptScore W2078940131C106208931 @default.
• W2078940131 hasConceptScore W2078940131C126322002 @default.
• W2078940131 hasConceptScore W2078940131C135763542 @default.
• W2078940131 hasConceptScore W2078940131C153209595 @default.
• W2078940131 hasConceptScore W2078940131C157410074 @default.
• W2078940131 hasConceptScore W2078940131C176080213 @default.
• W2078940131 hasConceptScore W2078940131C186413461 @default.

• next