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• W2078941338 abstract "As a cleavage enzyme of precursor TNF-α, the high expression level of ADAM17 in endothelial cells is an important factor in atherosclerosis. In this study, we demonstrate that ADAM17 is the target of miR-152. We found that miR-152 could reduce TNF precursor cleavage and inhibit cell proliferation and migration by targeting ADAM17 in human umbilical vein endothelial cells (HUVECs). Furthermore, the expression pattern of miR-152 and corresponding target ADAM17 was opposite in HUVECs under hypoxic conditions. The levels of circulating miR-152 in AS patient sera were lower than those detected in the sera of normal individuals. Our results indicate that miR-152 may be involved in the development of human atherosclerosis and could be used as diagnostic biomarker or therapeutic target in atherosclerosis." @default.
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• W2078941338 date "2014-05-08" @default.
• W2078941338 modified "2023-10-10" @default.
• W2078941338 title "MiR-152 reduces human umbilical vein endothelial cell proliferation and migration by targeting ADAM17" @default.
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• W2078941338 doi "https://doi.org/10.1016/j.febslet.2014.04.037" @default.
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