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• W2078941483 abstract "The co-crystal structure of the human acetyl-coenzyme A 2 (ACC2) carboxyl transferase domain and the reported compound CP-640186 (1b) suggested that two carbonyl groups are essential for potent ACC2 inhibition. By focusing on enhancing the interactions between the two carbonyl groups and the amino acid residues Gly2162 and Glu2230, we used ligand- and structure-based drug design to discover spirolactones bearing a 2-ureidobenzothiophene moiety" @default.
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• W2078941483 date "2011-11-01" @default.
• W2078941483 modified "2023-10-11" @default.
• W2078941483 title "Design, synthesis, and structure–activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors" @default.
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• W2078941483 doi "https://doi.org/10.1016/j.bmcl.2011.08.117" @default.
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