FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078945968> ?p ?o ?g. }

• W2078945968 endingPage "507" @default.
• W2078945968 startingPage "492" @default.
• W2078945968 abstract "We examined femora from adult AXB/BXA recombinant inbred (RI) mouse strains to identify skeletal traits that are functionally related and to determine how functional interactions among these traits contribute to genetic variability in whole-bone stiffness, strength, and toughness. Randomization of A/J and C57BL/6J genomic regions resulted in each adult male and female RI strain building mechanically functional femora by assembling unique sets of morphologic and tissue-quality traits. A correlation analysis was conducted using the mean trait values for each RI strain. A third of the 66 correlations examined were significant, indicating that many bone traits covaried or were functionally related. Path analysis revealed important functional interactions among bone slenderness, cortical thickness, and tissue mineral density. The path coefficients describing these functional relations were similar for both sexes. The causal relationship among these three traits suggested that cellular processes during growth simultaneously regulate bone slenderness, cortical thickness, and tissue mineral density so that the combination of traits is sufficiently stiff and strong to satisfy daily loading demands. A disadvantage of these functional interactions was that increases in tissue mineral density also deleteriously affected tissue ductility. Consequently, slender bones with high mineral density may be stiff and strong but they are also brittle. Thus, genetically randomized mouse strains revealed a basic biological paradigm that allows for flexibility in building bones that are functional for daily activities but that creates preferred sets of traits under extreme loading conditions. Genetic or environmental perturbations that alter these functional interactions during growth would be expected to lead to loss of function and suboptimal adult bone quality." @default.
• W2078945968 created "2016-06-24" @default.
• W2078945968 creator A5003696123 @default.
• W2078945968 creator A5022511735 @default.
• W2078945968 creator A5029261960 @default.
• W2078945968 creator A5030518549 @default.
• W2078945968 creator A5076090172 @default.
• W2078945968 creator A5080789213 @default.
• W2078945968 creator A5091606904 @default.
• W2078945968 date "2007-07-01" @default.
• W2078945968 modified "2023-10-16" @default.
• W2078945968 title "Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility" @default.
• W2078945968 cites W1753888616 @default.
• W2078945968 cites W1784626615 @default.
• W2078945968 cites W1947978704 @default.
• W2078945968 cites W1965220817 @default.
• W2078945968 cites W1966610596 @default.
• W2078945968 cites W1976839990 @default.
• W2078945968 cites W1978155211 @default.
• W2078945968 cites W1978763998 @default.
• W2078945968 cites W1978966296 @default.
• W2078945968 cites W1985270712 @default.
• W2078945968 cites W1992224892 @default.
• W2078945968 cites W1995278018 @default.
• W2078945968 cites W1996131009 @default.
• W2078945968 cites W1996955723 @default.
• W2078945968 cites W2001708988 @default.
• W2078945968 cites W2008994943 @default.
• W2078945968 cites W2010964594 @default.
• W2078945968 cites W2014209332 @default.
• W2078945968 cites W2017472612 @default.
• W2078945968 cites W2022825414 @default.
• W2078945968 cites W2023682507 @default.
• W2078945968 cites W2039659007 @default.
• W2078945968 cites W2040851406 @default.
• W2078945968 cites W2044443346 @default.
• W2078945968 cites W2051314051 @default.
• W2078945968 cites W2052777858 @default.
• W2078945968 cites W2056833001 @default.
• W2078945968 cites W2060662815 @default.
• W2078945968 cites W2064543888 @default.
• W2078945968 cites W2064986463 @default.
• W2078945968 cites W2065184840 @default.
• W2078945968 cites W2068555859 @default.
• W2078945968 cites W2068702879 @default.
• W2078945968 cites W2071108987 @default.
• W2078945968 cites W2075827267 @default.
• W2078945968 cites W2077130014 @default.
• W2078945968 cites W2077163152 @default.
• W2078945968 cites W2080103177 @default.
• W2078945968 cites W2096850955 @default.
• W2078945968 cites W2104943753 @default.
• W2078945968 cites W2108063837 @default.
• W2078945968 cites W2109764750 @default.
• W2078945968 cites W2110086807 @default.
• W2078945968 cites W2123017748 @default.
• W2078945968 cites W2125860227 @default.
• W2078945968 cites W2128761304 @default.
• W2078945968 cites W2130934825 @default.
• W2078945968 cites W2133059825 @default.
• W2078945968 cites W2139689251 @default.
• W2078945968 cites W2168555181 @default.
• W2078945968 cites W2289001133 @default.
• W2078945968 cites W397031418 @default.
• W2078945968 doi "https://doi.org/10.1007/s00335-007-9017-5" @default.
• W2078945968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1998883" @default.
• W2078945968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17557179" @default.
• W2078945968 hasPublicationYear "2007" @default.
• W2078945968 type Work @default.
• W2078945968 sameAs 2078945968 @default.
• W2078945968 citedByCount "71" @default.
• W2078945968 countsByYear W20789459682012 @default.
• W2078945968 countsByYear W20789459682013 @default.
• W2078945968 countsByYear W20789459682014 @default.
• W2078945968 countsByYear W20789459682015 @default.
• W2078945968 countsByYear W20789459682016 @default.
• W2078945968 countsByYear W20789459682017 @default.
• W2078945968 countsByYear W20789459682018 @default.
• W2078945968 countsByYear W20789459682019 @default.
• W2078945968 countsByYear W20789459682021 @default.
• W2078945968 countsByYear W20789459682023 @default.
• W2078945968 crossrefType "journal-article" @default.
• W2078945968 hasAuthorship W2078945968A5003696123 @default.
• W2078945968 hasAuthorship W2078945968A5022511735 @default.
• W2078945968 hasAuthorship W2078945968A5029261960 @default.
• W2078945968 hasAuthorship W2078945968A5030518549 @default.
• W2078945968 hasAuthorship W2078945968A5076090172 @default.
• W2078945968 hasAuthorship W2078945968A5080789213 @default.
• W2078945968 hasAuthorship W2078945968A5091606904 @default.
• W2078945968 hasBestOaLocation W20789459681 @default.
• W2078945968 hasConcept C104317684 @default.
• W2078945968 hasConcept C105702510 @default.
• W2078945968 hasConcept C105795698 @default.
• W2078945968 hasConcept C106934330 @default.
• W2078945968 hasConcept C127716648 @default.
• W2078945968 hasConcept C134018914 @default.
• W2078945968 hasConcept C199360897 @default.
• W2078945968 hasConcept C26207810 @default.

• next