FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078946446> ?p ?o ?g. }

• W2078946446 endingPage "1324" @default.
• W2078946446 startingPage "1319" @default.
• W2078946446 abstract "Abstract Thymosin β4(Tβ4), a 4.9-kDa polypeptide primarily known as a main G-actin–sequestering peptide, is present in high concentrations in various cells and in the circulation. We have found that Tβ4 upregulates the expression of plasminogen activator inhibitor 1 (PAI-1) in endothelial cells measured both at the level of mRNA and protein synthesis. This effect seems to be cell specific and was not observed when other cells such as human fibroblasts, PC3, and U937 were tested. Tβ4 significantly activated the PAI-1 promoter in EA.hy 926 cells transiently transfected either with plasmid p800LUC containing PAI-1 promoter fragment (–800 to +71) or the PAI-1 promoter linked with green fluorescent protein. Tβ4 mediated up-regulation of PAI-1 involved activation of the mitogen-activated protein kinase cascade. Furthermore, Tβ4 enhanced c-Fos/c-Jun DNA-binding activity to the activator protein 1 (AP-1)–like element (–59 to –52). The specificity of this binding activity was demonstrated by competition electrophoretic mobility shift assay and after transfection of EA.hy 926 cells with the mutated PAI-1 promoter. Taken together, these data indicate that, in response to Tβ4 stimulation, AP-1 activity increases to enhance PAI-1 transcription through its unique AP-1–like element at –59 to –52 in the PAI-1 promoter." @default.
• W2078946446 created "2016-06-24" @default.
• W2078946446 creator A5001934449 @default.
• W2078946446 creator A5005818802 @default.
• W2078946446 creator A5022361755 @default.
• W2078946446 creator A5034148569 @default.
• W2078946446 creator A5050985166 @default.
• W2078946446 creator A5063736852 @default.
• W2078946446 creator A5076277196 @default.
• W2078946446 creator A5078328470 @default.
• W2078946446 date "2004-02-15" @default.
• W2078946446 modified "2023-10-17" @default.
• W2078946446 title "Thymosin β4 induces the synthesis of plasminogen activator inhibitor 1 in cultured endothelial cells and increases its extracellular expression" @default.
• W2078946446 cites W1485904813 @default.
• W2078946446 cites W1489573122 @default.
• W2078946446 cites W1585344925 @default.
• W2078946446 cites W1587609746 @default.
• W2078946446 cites W1864853792 @default.
• W2078946446 cites W1967004332 @default.
• W2078946446 cites W1969078964 @default.
• W2078946446 cites W1973293243 @default.
• W2078946446 cites W1977581181 @default.
• W2078946446 cites W1987453246 @default.
• W2078946446 cites W1988117701 @default.
• W2078946446 cites W1991619876 @default.
• W2078946446 cites W2037955254 @default.
• W2078946446 cites W2039314838 @default.
• W2078946446 cites W2063865555 @default.
• W2078946446 cites W2069732826 @default.
• W2078946446 cites W2076400202 @default.
• W2078946446 cites W2090898772 @default.
• W2078946446 cites W2104642474 @default.
• W2078946446 cites W2114072364 @default.
• W2078946446 cites W2123498957 @default.
• W2078946446 cites W2161524185 @default.
• W2078946446 cites W2850745 @default.
• W2078946446 cites W4294216491 @default.
• W2078946446 cites W90771340 @default.
• W2078946446 cites W1970111556 @default.
• W2078946446 doi "https://doi.org/10.1182/blood-2003-04-1015" @default.
• W2078946446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14592829" @default.
• W2078946446 hasPublicationYear "2004" @default.
• W2078946446 type Work @default.
• W2078946446 sameAs 2078946446 @default.
• W2078946446 citedByCount "42" @default.
• W2078946446 countsByYear W20789464462012 @default.
• W2078946446 countsByYear W20789464462013 @default.
• W2078946446 countsByYear W20789464462015 @default.
• W2078946446 countsByYear W20789464462016 @default.
• W2078946446 countsByYear W20789464462018 @default.
• W2078946446 countsByYear W20789464462020 @default.
• W2078946446 countsByYear W20789464462022 @default.
• W2078946446 countsByYear W20789464462023 @default.
• W2078946446 crossrefType "journal-article" @default.
• W2078946446 hasAuthorship W2078946446A5001934449 @default.
• W2078946446 hasAuthorship W2078946446A5005818802 @default.
• W2078946446 hasAuthorship W2078946446A5022361755 @default.
• W2078946446 hasAuthorship W2078946446A5034148569 @default.
• W2078946446 hasAuthorship W2078946446A5050985166 @default.
• W2078946446 hasAuthorship W2078946446A5063736852 @default.
• W2078946446 hasAuthorship W2078946446A5076277196 @default.
• W2078946446 hasAuthorship W2078946446A5078328470 @default.
• W2078946446 hasConcept C104317684 @default.
• W2078946446 hasConcept C108634530 @default.
• W2078946446 hasConcept C134018914 @default.
• W2078946446 hasConcept C153911025 @default.
• W2078946446 hasConcept C183978625 @default.
• W2078946446 hasConcept C185592680 @default.
• W2078946446 hasConcept C2776572282 @default.
• W2078946446 hasConcept C2779679481 @default.
• W2078946446 hasConcept C2780675426 @default.
• W2078946446 hasConcept C2909373784 @default.
• W2078946446 hasConcept C54009773 @default.
• W2078946446 hasConcept C54355233 @default.
• W2078946446 hasConcept C55493867 @default.
• W2078946446 hasConcept C81885089 @default.
• W2078946446 hasConcept C86339819 @default.
• W2078946446 hasConcept C86803240 @default.
• W2078946446 hasConcept C88045685 @default.
• W2078946446 hasConceptScore W2078946446C104317684 @default.
• W2078946446 hasConceptScore W2078946446C108634530 @default.
• W2078946446 hasConceptScore W2078946446C134018914 @default.
• W2078946446 hasConceptScore W2078946446C153911025 @default.
• W2078946446 hasConceptScore W2078946446C183978625 @default.
• W2078946446 hasConceptScore W2078946446C185592680 @default.
• W2078946446 hasConceptScore W2078946446C2776572282 @default.
• W2078946446 hasConceptScore W2078946446C2779679481 @default.
• W2078946446 hasConceptScore W2078946446C2780675426 @default.
• W2078946446 hasConceptScore W2078946446C2909373784 @default.
• W2078946446 hasConceptScore W2078946446C54009773 @default.
• W2078946446 hasConceptScore W2078946446C54355233 @default.
• W2078946446 hasConceptScore W2078946446C55493867 @default.
• W2078946446 hasConceptScore W2078946446C81885089 @default.
• W2078946446 hasConceptScore W2078946446C86339819 @default.
• W2078946446 hasConceptScore W2078946446C86803240 @default.
• W2078946446 hasConceptScore W2078946446C88045685 @default.
• W2078946446 hasIssue "4" @default.
• W2078946446 hasLocation W20789464461 @default.

• next