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- W20789477 abstract "In chronic plumbism of children, elevated cer.ebrospinal fluid pressure has been reported. In an attempt to simulate this abnormality in an experimental animal, weanling rabbits were fed, in addition to a basal ration, lead intakes ranging from 0 to 100 mg/kg body weight/day for periods of either 10 or 12 weeks. Cerebrospinal fluid pressure was unaffected by lead intake. Concentrations of lead in the blood of the rabbits fed the highest lead intake were three times those in the blood of rabbits fed no lead. Similarly liver lead concentration was twelve times gre~~~r. As reported elsewhere, rabbits fed lead intakes ~ 25 mg exhibited red bloo~s'tippling, elevated red blood cell protoporphyrin concentrations, elevated urinary delta-aminolevulinic acid and phorphobilinogen concentrations and lowered erythrocyte de1taaminolevulinic acid dehydratase activities. Since these biochemical alterations also occur in children exhibiting plumbism, it can be tentatively concluded that the weanling rabbit's response to chronic plumbism, in respect to the occurrence of elevated cerebrospinal pressure, is not similar to the human's response. 'The research reported in this publication was supported in part by Federal funds made available through the provisions of the Hatch Act. Received for publication May 20, 1974." @default.
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- W20789477 date "1974-01-01" @default.
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- W20789477 title "Cerebrospinal Fluid Pressure in Weanling Rabbits with Chronic Plumbism" @default.
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