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• W2078950765 startingPage "7281" @default.
• W2078950765 abstract "MR elastography (MRE) enables the noninvasive determination of the viscoelastic behavior of human internal organs based on their response to oscillatory shear stress. An experiment was developed that combines multifrequency shear wave actuation with broad-band motion sensitization to extend the dynamic range of a single MRE examination. With this strategy, multiple wave images corresponding to different driving frequencies are simultaneously received and can be analyzed by evaluating the dispersion of the complex modulus over frequency. The technique was applied on the brain and liver of five healthy volunteers. Its repeatability was tested by four follow-up studies in each volunteer. Five standard rheological models (Maxwell, Voigt, Zener, Jeffreys and fractional Zener model) were assessed for their ability to reproduce the observed dispersion curves. The three-parameter Zener model was found to yield the most consistent results with two shear moduli μ1 = 0.84 ± 0.22 (1.36 ± 0.31) kPa, μ2 = 2.03 ± 0.19 (1.86 ± 0.34) kPa and one shear viscosity of η = 6.7 ± 1.3 (5.5 ± 1.6) Pa s (interindividual mean ± SD) in brain (liver) experiments. Significant differences between the rheological parameters of brain and liver were found for μ1 and η (P < 0.05), indicating that human brain is softer and possesses a higher viscosity than liver." @default.
• W2078950765 created "2016-06-24" @default.
• W2078950765 creator A5020825939 @default.
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• W2078950765 date "2007-11-23" @default.
• W2078950765 modified "2023-10-11" @default.
• W2078950765 title "Noninvasive assessment of the rheological behavior of human organs using multifrequency MR elastography: a study of brain and liver viscoelasticity" @default.
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• W2078950765 doi "https://doi.org/10.1088/0031-9155/52/24/006" @default.
• W2078950765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18065839" @default.
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