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• W2078956890 abstract "<h3>Objective</h3> We sought to investigate the effect of body mass index (BMI) on in vitro response to tocolytics. <h3>Study Design</h3> Myometrial biopsies were obtained at the time of scheduled cesarean deliveries from term nonlaboring women with BMI ≤29.9 (26.3 ± 1.3; n=7), 30-34.9 (31.8 ± 1.2; n=16), and ≥35 (39.5 ± 4.9; n=9). Tissue strips were suspended in organ chambers for isometric tension recording. The effects of cumulative doses (10⁻¹⁰ to 10⁻⁵ mol/L) of nifedipine or indomethacin on spontaneous uterine contractility were determined. Areas under the contraction curve were compared using 1-way analysis of variance with Tukey post hoc test. <h3>Results</h3> Myometrial response to tocolytics did not differ between the BMI groups. Nifedipine, but not indomethacin, significantly inhibited myometrial contractility independent of BMI. <h3>Conclusion</h3> BMI does not affect uterine response to tocolytics in isolated uterine tissue from term nonlaboring women." @default.
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• W2078956890 date "2010-09-01" @default.
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• W2078956890 title "Effect of maternal body mass index on in vitro response to tocolytics in term myometrium" @default.
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• W2078956890 doi "https://doi.org/10.1016/j.ajog.2010.05.029" @default.
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