FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078960259> ?p ?o ?g. }

• W2078960259 abstract "Endokinins, encoded by the human preprotachykinin C (PPT-C)/TAC4 gene, are peptides that consist of endokinin A (EKA), B (EKB), C (EKC) and D (EKD) and belong to the tachykinin family. Intrathecal injection of EKC/D (using the common carboxyl-terminal duodecapeptide in EKC and EKD) markedly attenuated the induction of thermal hyperalgesia and scratching behavior by intrathecal administration of substance P (SP), indicating that EKC/D has an antagonistic effect on the neurokinin 1 receptor (NK1R), SP-preferring receptor, at the spinal level; however, the pharmacological function of EKC/D at the periphery is not yet understood. Therefore, to clarify the effect of EKC/D on the peripheral tissue, the effect of subcutaneous injection of EKC/D on carrageenan-induced inflammation was examined. Subcutaneous injection of EKC/D attenuated an increase in paw volume following carrageenan-induced inflammation in a dose-dependent manner. Indeed, the increased paw volume was significantly decreased 40 min after treatment with 10(-4) M (10 nmol) and 10(-3) M (100 nmol) EKC/D (100 microl/rat). Similarly, injection of NK1R antagonists such as L-703,606 and Spantide I (10(-3) M) attenuated the increased paw volume following inflammation. Furthermore, the reduced withdrawal latency evoked by inflammation following subcutaneous injection of carrageenan was also dose-dependently attenuated by EKC/D administration. These results indicate that subcutaneous injection of EKC/D elicits an anti-inflammatory effect on carrageenan-induced inflammation." @default.
• W2078960259 created "2016-06-24" @default.
• W2078960259 creator A5015766404 @default.
• W2078960259 creator A5049170424 @default.
• W2078960259 creator A5049214496 @default.
• W2078960259 creator A5082181166 @default.
• W2078960259 creator A5083634372 @default.
• W2078960259 date "2010-09-01" @default.
• W2078960259 modified "2023-09-24" @default.
• W2078960259 title "Subcutaneous injection of endokinin C/D attenuates carrageenan-induced inflammation" @default.
• W2078960259 cites W1491269320 @default.
• W2078960259 cites W1968946931 @default.
• W2078960259 cites W1969080675 @default.
• W2078960259 cites W1974199545 @default.
• W2078960259 cites W1974620224 @default.
• W2078960259 cites W1975331387 @default.
• W2078960259 cites W2004624137 @default.
• W2078960259 cites W2011889630 @default.
• W2078960259 cites W2014007136 @default.
• W2078960259 cites W2019466854 @default.
• W2078960259 cites W2020578293 @default.
• W2078960259 cites W2044188934 @default.
• W2078960259 cites W2045072647 @default.
• W2078960259 cites W2058601469 @default.
• W2078960259 cites W2063161243 @default.
• W2078960259 cites W2067005918 @default.
• W2078960259 cites W2079183275 @default.
• W2078960259 cites W2082388368 @default.
• W2078960259 cites W2087454739 @default.
• W2078960259 cites W2090473343 @default.
• W2078960259 cites W2092623190 @default.
• W2078960259 cites W2092635728 @default.
• W2078960259 cites W2108922895 @default.
• W2078960259 cites W2117192323 @default.
• W2078960259 cites W2138235768 @default.
• W2078960259 cites W2142299867 @default.
• W2078960259 cites W2157236956 @default.
• W2078960259 cites W2163005269 @default.
• W2078960259 cites W2408902925 @default.
• W2078960259 cites W2413216127 @default.
• W2078960259 doi "https://doi.org/10.1016/j.peptides.2010.05.019" @default.
• W2078960259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20638946" @default.
• W2078960259 hasPublicationYear "2010" @default.
• W2078960259 type Work @default.
• W2078960259 sameAs 2078960259 @default.
• W2078960259 citedByCount "9" @default.
• W2078960259 countsByYear W20789602592013 @default.
• W2078960259 countsByYear W20789602592016 @default.
• W2078960259 countsByYear W20789602592017 @default.
• W2078960259 countsByYear W20789602592019 @default.
• W2078960259 crossrefType "journal-article" @default.
• W2078960259 hasAuthorship W2078960259A5015766404 @default.
• W2078960259 hasAuthorship W2078960259A5049170424 @default.
• W2078960259 hasAuthorship W2078960259A5049214496 @default.
• W2078960259 hasAuthorship W2078960259A5082181166 @default.
• W2078960259 hasAuthorship W2078960259A5083634372 @default.
• W2078960259 hasConcept C118303440 @default.
• W2078960259 hasConcept C134018914 @default.
• W2078960259 hasConcept C15490471 @default.
• W2078960259 hasConcept C170493617 @default.
• W2078960259 hasConcept C185592680 @default.
• W2078960259 hasConcept C203014093 @default.
• W2078960259 hasConcept C2776390293 @default.
• W2078960259 hasConcept C2776533618 @default.
• W2078960259 hasConcept C2776914184 @default.
• W2078960259 hasConcept C2777056410 @default.
• W2078960259 hasConcept C2779245659 @default.
• W2078960259 hasConcept C2781227287 @default.
• W2078960259 hasConcept C55493867 @default.
• W2078960259 hasConcept C71924100 @default.
• W2078960259 hasConcept C98274493 @default.
• W2078960259 hasConceptScore W2078960259C118303440 @default.
• W2078960259 hasConceptScore W2078960259C134018914 @default.
• W2078960259 hasConceptScore W2078960259C15490471 @default.
• W2078960259 hasConceptScore W2078960259C170493617 @default.
• W2078960259 hasConceptScore W2078960259C185592680 @default.
• W2078960259 hasConceptScore W2078960259C203014093 @default.
• W2078960259 hasConceptScore W2078960259C2776390293 @default.
• W2078960259 hasConceptScore W2078960259C2776533618 @default.
• W2078960259 hasConceptScore W2078960259C2776914184 @default.
• W2078960259 hasConceptScore W2078960259C2777056410 @default.
• W2078960259 hasConceptScore W2078960259C2779245659 @default.
• W2078960259 hasConceptScore W2078960259C2781227287 @default.
• W2078960259 hasConceptScore W2078960259C55493867 @default.
• W2078960259 hasConceptScore W2078960259C71924100 @default.
• W2078960259 hasConceptScore W2078960259C98274493 @default.
• W2078960259 hasLocation W20789602591 @default.
• W2078960259 hasLocation W20789602592 @default.
• W2078960259 hasOpenAccess W2078960259 @default.
• W2078960259 hasPrimaryLocation W20789602591 @default.
• W2078960259 hasRelatedWork W1491269320 @default.
• W2078960259 hasRelatedWork W1966150192 @default.
• W2078960259 hasRelatedWork W1974199545 @default.
• W2078960259 hasRelatedWork W1975331387 @default.
• W2078960259 hasRelatedWork W1997127543 @default.
• W2078960259 hasRelatedWork W2005611046 @default.
• W2078960259 hasRelatedWork W2020132991 @default.
• W2078960259 hasRelatedWork W2020857881 @default.
• W2078960259 hasRelatedWork W2035980199 @default.
• W2078960259 hasRelatedWork W2037925864 @default.

• next