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- W2078960359 abstract "Enkephalin actions on the voltage-gated Ca channel were studied under voltage clamp in the neuroblastoma×glioma hybrid cell line, NG 108-15. We found that in sodium-free external solutions containing Ba2+ (20 mM), a depolarization step pulse from a holding potential of −50 mV evoked both a rapidly decaying inward current and a sustained inward current similar to those described in other preparations. External application of 1 μM [d-Thr2, Leu5]enkephalin-Thr (DTLET), an agonist at the δ-opioid receptors specifically inhibited the sustained inward current. Naloxone, an antagonist at this receptor, blocked the effect of DTLET. Furthermore, this effect of DTLET was not observed if the cells were dialyzed with a low Ca2+ internal buffer solution ([Ca2+]i < 10−9M). We conclude that in neuroblastoma cells: (1) there is a functional coupling between δ-receptors and voltage-gated sustained Ca channels, and (2) the coupling is mediated by intracellular free Ca ions." @default.
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- W2078960359 date "1987-07-01" @default.
- W2078960359 modified "2023-10-18" @default.
- W2078960359 title "Activation of enkephalin receptors reduces calcium conductance in neuroblastoma cells" @default.
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- W2078960359 doi "https://doi.org/10.1016/0006-8993(87)90220-4" @default.
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