FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W207896504> ?p ?o ?g. }

• W207896504 endingPage "42" @default.
• W207896504 startingPage "34" @default.
• W207896504 abstract "Melatonin is involved in various neuronal functions such as circadian rhythmicity and thermoregulation. Melatonin has a wide range of pharmacologically effective concentration levels from the nanomolar to millimolar levels. Recently, the antiepileptic effect of high dose melatonin has been the focus of clinical studies; however, its detailed mechanism especially in relation to neurotransmitter release and synaptic transmission remains unclear. We studied the effect of melatonin at high concentrations on the neurotransmitter release by monitoring norepinephrine release in PC12 cells, and excitatory postsynaptic potential in rat hippocampal slices. Melatonin inhibits the 70mM K(+)-induced Ca(2+) increase at millimolar levels without effect on bradykinin-triggered Ca(2+) increase in PC12 cells. Melatonin (1mM) did not affect A2A adenosine receptor-evoked cAMP production, and classical melatonin receptor antagonists did not reverse the melatonin-induced inhibitory effect, suggesting G-protein coupled receptor independency. Melatonin inhibits the 70mM K(+)-induced norepinephrine release at a similar effective concentration range in PC12 cells. We confirmed that melatonin (100µM) inhibits excitatory synaptic transmission of the hippocampal Schaffer collateral pathway with the decrease in basal synaptic transmission and the increase in paired pulse ratio. These results show that melatonin inhibits neurotransmitter release through the blocking of voltage-sensitive Ca(2+) channels and suggest a possible mechanism for the antiepileptic effect of melatonin." @default.
• W207896504 created "2016-06-24" @default.
• W207896504 creator A5003925937 @default.
• W207896504 creator A5022553207 @default.
• W207896504 creator A5034989160 @default.
• W207896504 creator A5059119744 @default.
• W207896504 creator A5062738042 @default.
• W207896504 creator A5069695007 @default.
• W207896504 date "2014-04-01" @default.
• W207896504 modified "2023-10-15" @default.
• W207896504 title "Melatonin inhibits voltage-sensitive Ca2+ channel-mediated neurotransmitter release" @default.
• W207896504 cites W1541441850 @default.
• W207896504 cites W1554079895 @default.
• W207896504 cites W1798409403 @default.
• W207896504 cites W1965532359 @default.
• W207896504 cites W1965728794 @default.
• W207896504 cites W1967181740 @default.
• W207896504 cites W1972107530 @default.
• W207896504 cites W1973238853 @default.
• W207896504 cites W1984261954 @default.
• W207896504 cites W1984989652 @default.
• W207896504 cites W1993650023 @default.
• W207896504 cites W2016868037 @default.
• W207896504 cites W2018345928 @default.
• W207896504 cites W2019016101 @default.
• W207896504 cites W2019188849 @default.
• W207896504 cites W2021172802 @default.
• W207896504 cites W2032589758 @default.
• W207896504 cites W2034132165 @default.
• W207896504 cites W2042036678 @default.
• W207896504 cites W2043774516 @default.
• W207896504 cites W2050974910 @default.
• W207896504 cites W2056570708 @default.
• W207896504 cites W2061869669 @default.
• W207896504 cites W2062325168 @default.
• W207896504 cites W2068283019 @default.
• W207896504 cites W2068909677 @default.
• W207896504 cites W2071019848 @default.
• W207896504 cites W2072273888 @default.
• W207896504 cites W2077440925 @default.
• W207896504 cites W2080597613 @default.
• W207896504 cites W2093614153 @default.
• W207896504 cites W2098743909 @default.
• W207896504 cites W2125877971 @default.
• W207896504 cites W2131924401 @default.
• W207896504 cites W2139474809 @default.
• W207896504 cites W2151126276 @default.
• W207896504 cites W2152544375 @default.
• W207896504 cites W2160485730 @default.
• W207896504 doi "https://doi.org/10.1016/j.brainres.2014.02.023" @default.
• W207896504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24560601" @default.
• W207896504 hasPublicationYear "2014" @default.
• W207896504 type Work @default.
• W207896504 sameAs 207896504 @default.
• W207896504 citedByCount "24" @default.
• W207896504 countsByYear W2078965042015 @default.
• W207896504 countsByYear W2078965042016 @default.
• W207896504 countsByYear W2078965042017 @default.
• W207896504 countsByYear W2078965042018 @default.
• W207896504 countsByYear W2078965042019 @default.
• W207896504 countsByYear W2078965042020 @default.
• W207896504 countsByYear W2078965042021 @default.
• W207896504 countsByYear W2078965042023 @default.
• W207896504 crossrefType "journal-article" @default.
• W207896504 hasAuthorship W207896504A5003925937 @default.
• W207896504 hasAuthorship W207896504A5022553207 @default.
• W207896504 hasAuthorship W207896504A5034989160 @default.
• W207896504 hasAuthorship W207896504A5059119744 @default.
• W207896504 hasAuthorship W207896504A5062738042 @default.
• W207896504 hasAuthorship W207896504A5069695007 @default.
• W207896504 hasConcept C112592302 @default.
• W207896504 hasConcept C126322002 @default.
• W207896504 hasConcept C134018914 @default.
• W207896504 hasConcept C170493617 @default.
• W207896504 hasConcept C17077164 @default.
• W207896504 hasConcept C185592680 @default.
• W207896504 hasConcept C200170125 @default.
• W207896504 hasConcept C2776219046 @default.
• W207896504 hasConcept C2778182776 @default.
• W207896504 hasConcept C529278444 @default.
• W207896504 hasConcept C71924100 @default.
• W207896504 hasConcept C86803240 @default.
• W207896504 hasConceptScore W207896504C112592302 @default.
• W207896504 hasConceptScore W207896504C126322002 @default.
• W207896504 hasConceptScore W207896504C134018914 @default.
• W207896504 hasConceptScore W207896504C170493617 @default.
• W207896504 hasConceptScore W207896504C17077164 @default.
• W207896504 hasConceptScore W207896504C185592680 @default.
• W207896504 hasConceptScore W207896504C200170125 @default.
• W207896504 hasConceptScore W207896504C2776219046 @default.
• W207896504 hasConceptScore W207896504C2778182776 @default.
• W207896504 hasConceptScore W207896504C529278444 @default.
• W207896504 hasConceptScore W207896504C71924100 @default.
• W207896504 hasConceptScore W207896504C86803240 @default.
• W207896504 hasFunder F4320322120 @default.
• W207896504 hasFunder F4320331163 @default.
• W207896504 hasLocation W2078965041 @default.
• W207896504 hasLocation W2078965042 @default.

• next