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- W2078965957 abstract "Thymus-deprived and normal DBA/2 mice show no difference in the immune response to bacteriophage fd, an antigen for which these mice are low responders. Thymectomy in high responders reduces the response 100–1000-fold. The immune response to SRBC in the deprived and normal DBA/2 has also been tested. The drastically reduced response in deprived mice shows that these animals indeed lack thymic influence.Low responder DBA/2 mice have a weak primary and secondary response to the phage fd. They largely produce IgM, but in spite of that, they are able to build up an immunological memory. The data suggest that the inability of DBA/2 mice to respond well to fd is a thymus deficiency. This observation is supported by the finding that polyacrylic acid converts low responder DBA/2 mice to high responders. Genetically thymusless (nude) C57BL/6-nu/nu mice are low responders, but, in contrast to DBA/2, are unable to form an immunological memory. The secondary response is identical in height and rate with a primary response." @default.
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- W2078965957 date "1972-12-01" @default.
- W2078965957 modified "2023-10-03" @default.
- W2078965957 title "The immune response to phage fd in normal and thymus-deprived animals of a low responding inbred strain and in genetically thymusless mice" @default.
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- W2078965957 doi "https://doi.org/10.1002/eji.1830020613" @default.
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