FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078967087> ?p ?o ?g. }

• W2078967087 endingPage "75" @default.
• W2078967087 startingPage "69" @default.
• W2078967087 abstract "Varicella zoster virus (VZV) is a well-known cause of infectious uveitis. The aim of this study was to characterize the VZV-specific T-cell response in eyes of patients with VZV-induced uveitis. T-cell lines (TCL) were generated by mitogenic stimulation of intra-ocular fluid (IOF) samples obtained from eight patients with VZV-induced uveitis. Two patients with herpes simplex virus (HSV)-induced uveitis were included as disease controls. Characterization of individual T-cells in the TCL was performed by stimulating the TCL with mock, HSV-1 and VZV antigen pulsed autologous B cells and subsequent flow cytometric analyses. Virus specificity and phenotype of the T-cells were identified by simultaneous detection of intracellular gamma interferon and cell surface markers CD4, CD8, CD3 or T-cell receptor (TCR) beta chain variable region (TCRBV) usage. The TCL obtained from patients with HSV-1-induced uveitis contained higher numbers of T-cells reactive to HSV-1 compared to VZV. VZV-specific T-cells were detected in all TCL of the patients diagnosed with VZV-induced uveitis. Four out of six TCL obtained from patients with VZV-induced uveitis that were assayed for both viruses, contained higher numbers of T-cells reactive to VZV compared to HSV-1. Detailed analyses of the TCL of two patients demonstrated that the VZV reactivity within the assayed TCL was dominated by T-cells expressing one specific TCRBV gene. The data implicate that VZV-reactive T-cells infiltrate and participate in the local inflammatory response in eyes of patients with VZV-induced uveitis." @default.
• W2078967087 created "2016-06-24" @default.
• W2078967087 creator A5012442242 @default.
• W2078967087 creator A5040091715 @default.
• W2078967087 creator A5049618841 @default.
• W2078967087 creator A5066572252 @default.
• W2078967087 creator A5040230970 @default.
• W2078967087 date "2006-07-01" @default.
• W2078967087 modified "2023-10-16" @default.
• W2078967087 title "Characterization of the varicella zoster virus (VZV)-specific intra-ocular T-cell response in patients with VZV-induced uveitis" @default.
• W2078967087 cites W1495829907 @default.
• W2078967087 cites W179964171 @default.
• W2078967087 cites W1863343937 @default.
• W2078967087 cites W1897410289 @default.
• W2078967087 cites W1966161103 @default.
• W2078967087 cites W1973664301 @default.
• W2078967087 cites W1976342692 @default.
• W2078967087 cites W2015358085 @default.
• W2078967087 cites W2020094108 @default.
• W2078967087 cites W2033193447 @default.
• W2078967087 cites W2040570036 @default.
• W2078967087 cites W2054955386 @default.
• W2078967087 cites W2078576561 @default.
• W2078967087 cites W2089226382 @default.
• W2078967087 cites W2092291963 @default.
• W2078967087 cites W2096242864 @default.
• W2078967087 cites W2098932673 @default.
• W2078967087 cites W2110275809 @default.
• W2078967087 cites W2114493619 @default.
• W2078967087 cites W2115698314 @default.
• W2078967087 cites W2118902198 @default.
• W2078967087 cites W2132828342 @default.
• W2078967087 cites W2153293687 @default.
• W2078967087 cites W2155252245 @default.
• W2078967087 cites W2161150322 @default.
• W2078967087 cites W2167024304 @default.
• W2078967087 cites W2167295408 @default.
• W2078967087 cites W2167904130 @default.
• W2078967087 doi "https://doi.org/10.1016/j.exer.2005.11.008" @default.
• W2078967087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16530754" @default.
• W2078967087 hasPublicationYear "2006" @default.
• W2078967087 type Work @default.
• W2078967087 sameAs 2078967087 @default.
• W2078967087 citedByCount "14" @default.
• W2078967087 countsByYear W20789670872012 @default.
• W2078967087 countsByYear W20789670872013 @default.
• W2078967087 countsByYear W20789670872014 @default.
• W2078967087 countsByYear W20789670872015 @default.
• W2078967087 crossrefType "journal-article" @default.
• W2078967087 hasAuthorship W2078967087A5012442242 @default.
• W2078967087 hasAuthorship W2078967087A5040091715 @default.
• W2078967087 hasAuthorship W2078967087A5040230970 @default.
• W2078967087 hasAuthorship W2078967087A5049618841 @default.
• W2078967087 hasAuthorship W2078967087A5066572252 @default.
• W2078967087 hasConcept C147483822 @default.
• W2078967087 hasConcept C154317977 @default.
• W2078967087 hasConcept C159047783 @default.
• W2078967087 hasConcept C167672396 @default.
• W2078967087 hasConcept C19317047 @default.
• W2078967087 hasConcept C202751555 @default.
• W2078967087 hasConcept C203014093 @default.
• W2078967087 hasConcept C2522874641 @default.
• W2078967087 hasConcept C2776090121 @default.
• W2078967087 hasConcept C2776159415 @default.
• W2078967087 hasConcept C2776194053 @default.
• W2078967087 hasConcept C2781196997 @default.
• W2078967087 hasConcept C55493867 @default.
• W2078967087 hasConcept C71924100 @default.
• W2078967087 hasConcept C86803240 @default.
• W2078967087 hasConcept C8891405 @default.
• W2078967087 hasConceptScore W2078967087C147483822 @default.
• W2078967087 hasConceptScore W2078967087C154317977 @default.
• W2078967087 hasConceptScore W2078967087C159047783 @default.
• W2078967087 hasConceptScore W2078967087C167672396 @default.
• W2078967087 hasConceptScore W2078967087C19317047 @default.
• W2078967087 hasConceptScore W2078967087C202751555 @default.
• W2078967087 hasConceptScore W2078967087C203014093 @default.
• W2078967087 hasConceptScore W2078967087C2522874641 @default.
• W2078967087 hasConceptScore W2078967087C2776090121 @default.
• W2078967087 hasConceptScore W2078967087C2776159415 @default.
• W2078967087 hasConceptScore W2078967087C2776194053 @default.
• W2078967087 hasConceptScore W2078967087C2781196997 @default.
• W2078967087 hasConceptScore W2078967087C55493867 @default.
• W2078967087 hasConceptScore W2078967087C71924100 @default.
• W2078967087 hasConceptScore W2078967087C86803240 @default.
• W2078967087 hasConceptScore W2078967087C8891405 @default.
• W2078967087 hasIssue "1" @default.
• W2078967087 hasLocation W20789670871 @default.
• W2078967087 hasLocation W20789670872 @default.
• W2078967087 hasOpenAccess W2078967087 @default.
• W2078967087 hasPrimaryLocation W20789670871 @default.
• W2078967087 hasRelatedWork W1969542161 @default.
• W2078967087 hasRelatedWork W1980025726 @default.
• W2078967087 hasRelatedWork W1996773663 @default.
• W2078967087 hasRelatedWork W2012199451 @default.
• W2078967087 hasRelatedWork W2048716591 @default.
• W2078967087 hasRelatedWork W2052876854 @default.
• W2078967087 hasRelatedWork W2394822632 @default.

• next