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• W2078967541 abstract "Inherited germline mutations in the tumor suppressor gene BRCA1 predispose individuals to early onset breast and ovarian cancer [1Venkitaraman A.R. Cancer susceptibility and the functions of BRCA1 and BRCA2.Cell. 2002; 108: 171-182Abstract Full Text Full Text PDF PubMed Scopus (1312) Google Scholar]. BRCA1 together with its structurally related partner BARD1 is required for homologous recombination and DNA double-strand break repair, but how they perform these functions remains elusive [2Scully R. Ganesan S. Vlasakova K. Chen J. Socolovsky M. Livingston D.M. Genetic analysis of BRCA1 function in a defined tumor cell line.Mol. Cell. 1999; 4: 1093-1099Abstract Full Text Full Text PDF PubMed Scopus (316) Google Scholar, 3Moynahan M.E. Chiu J.W. Koller B.H. Jasin M. Brca1 controls homology-directed DNA repair.Mol. Cell. 1999; 4: 511-518Abstract Full Text Full Text PDF PubMed Scopus (969) Google Scholar]. As part of a comprehensive search for DNA repair genes in C. elegans, we identified a BARD1 ortholog. In protein interaction screens, Ce-BRD-1 was found to interact with components of the sumoylation pathway, the TACC domain protein TAC-1, and most importantly, a homolog of mammalian BRCA1. We show that animals depleted for either Ce-brc-1 or Ce-brd-1 display similar abnormalities, including a high incidence of males, elevated levels of p53-dependent germ cell death before and after irradiation, and impaired progeny survival and chromosome fragmentation after irradiation. Furthermore, depletion of ubc-9 and tac-1 leads to radiation sensitivity and a high incidence of males, respectively, potentially linking these genes to the C. elegans BRCA1 pathway. Our findings support a shared role for Ce-BRC-1 and Ce-BRD-1 in C. elegans DNA repair processes, and this role will permit studies of the BRCA1 pathway in an organism amenable to rapid genetic and biochemical analysis." @default.
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• W2078967541 date "2004-01-01" @default.
• W2078967541 modified "2023-09-25" @default.
• W2078967541 title "BRCA1/BARD1 Orthologs Required for DNA Repair in Caenorhabditis elegans" @default.
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• W2078967541 doi "https://doi.org/10.1016/j.cub.2003.11.029" @default.
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