FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078968211> ?p ?o ?g. }

• W2078968211 endingPage "408" @default.
• W2078968211 startingPage "397" @default.
• W2078968211 abstract "Contraction plays a major role in wound healing and is inevitably mediated through the mechanical interaction of fibroblast cytoskeleton and integrins with their extracellular matrix ligands. Cell–matrix attachment is critical for such events. In human dermal fibroblasts most such interactions are mediated by the β1‐type integrins. This study investigated the role played by key components in this system, notably fibronectin, vitronectin, and integrin subcomponents α2 and α5, which recognize collagen and fibronectin. Inhibition of adhesion through these ligands was studied either by antibody blocking or with fibronectin and/or vitronectin depletion. Functional effects of inhibition were monitored as force generation in collagen‐glycosaminoglycan (Integra TM ) sponges, over 20 hours using a culture force monitor. Dose and time‐course inhibition studies indicated that initial attachment and force generation (approx. 0–5 hours postseeding) was through fibronectin receptors and this was followed by vitronectin ligand and receptor utilization (4 hours onward). Utilization of the collagen integrin subcomponent α2 appeared to be increasingly important between 6 and 16 hours and dominant thereafter. Additionally, there was evidence for functional interdependence between the three ligand systems fibronectin, vitronectin, and collagen. We propose that there is a short cascade of sequential integrin–ligand interactions as cells attach to, extend through, and eventually contract their matrix. (WOUND REP REG 2002;10:–408)" @default.
• W2078968211 created "2016-06-24" @default.
• W2078968211 creator A5019247928 @default.
• W2078968211 creator A5030706452 @default.
• W2078968211 creator A5031658340 @default.
• W2078968211 creator A5037169815 @default.
• W2078968211 creator A5072316687 @default.
• W2078968211 creator A5085100888 @default.
• W2078968211 date "2002-11-01" @default.
• W2078968211 modified "2023-10-15" @default.
• W2078968211 title "Evidence for sequential utilization of fibronectin, vitronectin, and collagen during fibroblast-mediated collagen contraction" @default.
• W2078968211 cites W166803931 @default.
• W2078968211 cites W175266247 @default.
• W2078968211 cites W1806064940 @default.
• W2078968211 cites W1831218435 @default.
• W2078968211 cites W1923175924 @default.
• W2078968211 cites W1964195356 @default.
• W2078968211 cites W1968647003 @default.
• W2078968211 cites W1969844396 @default.
• W2078968211 cites W1973474133 @default.
• W2078968211 cites W1976439168 @default.
• W2078968211 cites W1981284178 @default.
• W2078968211 cites W1984729535 @default.
• W2078968211 cites W1986638085 @default.
• W2078968211 cites W1988264024 @default.
• W2078968211 cites W1988870663 @default.
• W2078968211 cites W1991592903 @default.
• W2078968211 cites W1993983073 @default.
• W2078968211 cites W1995062602 @default.
• W2078968211 cites W1998765083 @default.
• W2078968211 cites W2002369146 @default.
• W2078968211 cites W2002499520 @default.
• W2078968211 cites W2004414761 @default.
• W2078968211 cites W2013272129 @default.
• W2078968211 cites W2013672165 @default.
• W2078968211 cites W2016193552 @default.
• W2078968211 cites W2016904168 @default.
• W2078968211 cites W2017085884 @default.
• W2078968211 cites W2018785688 @default.
• W2078968211 cites W2021655686 @default.
• W2078968211 cites W2024373128 @default.
• W2078968211 cites W2028510043 @default.
• W2078968211 cites W2028598902 @default.
• W2078968211 cites W2029231027 @default.
• W2078968211 cites W2034055040 @default.
• W2078968211 cites W2036232712 @default.
• W2078968211 cites W2036290474 @default.
• W2078968211 cites W2049204288 @default.
• W2078968211 cites W2073908835 @default.
• W2078968211 cites W2077776035 @default.
• W2078968211 cites W2081861317 @default.
• W2078968211 cites W2083174752 @default.
• W2078968211 cites W2084310564 @default.
• W2078968211 cites W2084334139 @default.
• W2078968211 cites W2085804760 @default.
• W2078968211 cites W2105300288 @default.
• W2078968211 cites W2106929134 @default.
• W2078968211 cites W2109594092 @default.
• W2078968211 cites W2110586785 @default.
• W2078968211 cites W2120936884 @default.
• W2078968211 cites W2129743419 @default.
• W2078968211 cites W2131750143 @default.
• W2078968211 cites W2183816965 @default.
• W2078968211 cites W2188060873 @default.
• W2078968211 cites W4250269443 @default.
• W2078968211 cites W51115169 @default.
• W2078968211 doi "https://doi.org/10.1046/j.1524-475x.2002.10609.x" @default.
• W2078968211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12453144" @default.
• W2078968211 hasPublicationYear "2002" @default.
• W2078968211 type Work @default.
• W2078968211 sameAs 2078968211 @default.
• W2078968211 citedByCount "79" @default.
• W2078968211 countsByYear W20789682112012 @default.
• W2078968211 countsByYear W20789682112013 @default.
• W2078968211 countsByYear W20789682112014 @default.
• W2078968211 countsByYear W20789682112015 @default.
• W2078968211 countsByYear W20789682112016 @default.
• W2078968211 countsByYear W20789682112017 @default.
• W2078968211 countsByYear W20789682112018 @default.
• W2078968211 countsByYear W20789682112019 @default.
• W2078968211 countsByYear W20789682112020 @default.
• W2078968211 countsByYear W20789682112021 @default.
• W2078968211 countsByYear W20789682112022 @default.
• W2078968211 countsByYear W20789682112023 @default.
• W2078968211 crossrefType "journal-article" @default.
• W2078968211 hasAuthorship W2078968211A5019247928 @default.
• W2078968211 hasAuthorship W2078968211A5030706452 @default.
• W2078968211 hasAuthorship W2078968211A5031658340 @default.
• W2078968211 hasAuthorship W2078968211A5037169815 @default.
• W2078968211 hasAuthorship W2078968211A5072316687 @default.
• W2078968211 hasAuthorship W2078968211A5085100888 @default.
• W2078968211 hasConcept C119524353 @default.
• W2078968211 hasConcept C1491633281 @default.
• W2078968211 hasConcept C151166631 @default.
• W2078968211 hasConcept C164144092 @default.
• W2078968211 hasConcept C170493617 @default.
• W2078968211 hasConcept C185592680 @default.
• W2078968211 hasConcept C189165786 @default.

• next