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- W2078970058 abstract "Steroid-resistant acute cellular rejection (ACR) and chronic rejection (CR) are still major concerns after intestinal transplantation. We report our experience from a single center on 48 adults recipients using 49 grafts from 2001 to 2011, immunosuppressing them initially with daclizumab initially and later Alemtuzumab. Overall patient survival was 41.9% at 10 years while graft survival was 38.5%. The steroid-resistant ACR population of 14 recipients (28.5%) experienced 50% mortality mainly due to sepsis, while the five (8%) CR recipients, included two survivors. All but 1 graft was placed without a liver. CR was often preceded by ACR episodes. Mortality related to steroid-resistant ACR and CR still affects the intestinal transplant population despite induction/preconditioning, especially in the absence of a protective liver effect of the liver. New immunosuppressive strategies are needed." @default.
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- W2078970058 date "2013-06-01" @default.
- W2078970058 modified "2023-10-14" @default.
- W2078970058 title "Mortality After Steroid-Resistant Acute Cellular Rejection and Chronic Rejection Episodes in Adult Intestinal Transplants: Report From a Single Center in Induction/Preconditioning Era" @default.
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- W2078970058 doi "https://doi.org/10.1016/j.transproceed.2012.09.124" @default.
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