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- W2078971030 abstract "Background Pleomorphic xanthoastrocytoma (PXA) is a rare astrocytic tumor occurring primarily in children and young adults. The superficial location of the tumor facilitates gross total resection (GTR) thus conferring a relatively favorable outcome with a reported 10-year overall survival (OS) of 70%. Procedure A retrospective case analysis of children and adolescents diagnosed and treated with PXA in our institution between January 1980 and March 2009 and a literature review. Results 85.7% of our patients with a GTR were recurrence free. Only one of seven patients with less than a GTR did not recur and median time to recurrence was under 1 year in patients who did not have a GTR. Two of three patients with anaplastic features or malignant transformation at initial presentation progressed. Five-year OS and recurrence free survival (RFS) was 85.7% and 49%, respectively. Conclusions GTR is the preferred treatment modality for PXA. Anaplastic features, though uncommon at initial presentation, confer a less favorable outcome. The role of adjuvant therapy with primary and recurrent anaplastic PXAs, especially when complete resection is not feasible, warrants further study. Pediatr Blood Cancer. 2010;55:290–294. © 2010 Wiley–Liss, Inc." @default.
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- W2078971030 date "2010-03-27" @default.
- W2078971030 modified "2023-09-29" @default.
- W2078971030 title "Pleomorphic xanthoastrocytoma in children and adolescents" @default.
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- W2078971030 doi "https://doi.org/10.1002/pbc.22490" @default.
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