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- W207897108 abstract "Lipopolysaccharide (LPS), a major constituent of the outer membrane of gram-native bacteria, potently stimulates host innate immune responses and upregulates IL-8 and MCP-1 gene expression and secretion. The activation of hepatic stellate cells (HSCs) is recognized as the key event of hepatic inflammation. NF-kB, an oxidant-sensitive transcription factor, has been associated with the development of the activated phenotype, the expression of proinflammatory genes. This study was to investigate whether LPS induces the production of reactive oxygen species (ROS) in HSCs, and whether LPS-induced ROS generation mediates the activation of NF-kB which mediates induction of IL-8 in HSC. Finally, we investigated the effect of antioxidant nutrients, NAC and lipoic acid, on LPS-induced IL-8 expression in HSCs. The results show that LPS induces ROS production, the activation of NF-kB and induction of IL-8, which may be suppressed by treatment of NAC and lipoic acid in HSCs. (This study was supported by Brain Korea 21 Project, College of Human Ecology, Yonsei University)" @default.
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- W207897108 date "2007-01-01" @default.
- W207897108 modified "2023-10-18" @default.
- W207897108 title "Antioxidant nutrients inhibit LPS‐induced IL‐8 expression in human hepatic stellate cells" @default.
- W207897108 doi "https://doi.org/10.1096/fasebj.21.6.a1107-c" @default.
- W207897108 hasPublicationYear "2007" @default.
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