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- W2078976765 abstract "Abstract Of several known inhibitors of ornithine decarboxylase activity, only 1,4-diamino-2-butanone (DAB) inhibited spore germination of Mucor rouxii. Drug-exposed cells went through the phase of spherical growth attaining huge cell volumes, but were unable to germinate. The same phenomenon occurred irrespective of the growth medium in several species of Mucorales. DAB barely inhibited the biosynthesis of proteins and DNA during the phase of spherical growth. Higher levels of inhibition were observed at later growth periods. The addition of DAB to the growth medium decreased the cellular levels of polyamines. Removal of DAB or addition of putrescine reversed the inhibitory effect. Cycloheximide and actinomycin D completely blocked the reversal of the inhibition of germination after DAB removal or addition of putrescine, whereas hydroxyurea gave variable intermediate values of inhibition. It is suggested that the DAB effect can be interpreted as a requirement of high levels of polyamines for the change of growth patterns from spherical to apical in the fungi studied." @default.
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- W2078976765 date "1987-12-01" @default.
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- W2078976765 title "Effect of ornithine decarboxylase inhibitors on the germination of sporangiospores of mucorales" @default.
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- W2078976765 doi "https://doi.org/10.1016/0147-5975(87)90017-x" @default.
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