FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078978286> ?p ?o ?g. }

• W2078978286 endingPage "422" @default.
• W2078978286 startingPage "409" @default.
• W2078978286 abstract "The epidermal growth factor receptor (EGFR) functions in various cellular physiological processes such as proliferation, differentiation, and motility. Although recent studies have reported that EGFR signaling is involved in osteoclast recruitment and formation, the molecular mechanism of EGFR signaling for the regulation of osteoclastogenesis remains unclear. We investigated the role of the EGFR in osteoclast differentiation and survival and show that the expression of the EGFR was highly up-regulated by receptor activator of nuclear factor-κB ligand (RANKL) during osteoclast differentiation. EGFR-specific tyrosine kinase inhibitors and EGFR knockdown blocked RANKL-dependent osteoclast formation, suggesting that EGFR signaling plays an important role in osteoclastogenesis. EGFR inhibition impaired the RANKL-mediated activation of osteoclastogenic signaling pathways, including c-Jun N-terminal kinase (JNK), NF-κB, and Akt/protein kinase B (PKB). In addition, EGFR inhibition in differentiated osteoclasts caused apoptosis through caspase activation. Inhibition of the phosphoinositide-3 kinase (PI3K)-Akt/PKB pathway and subsequent activation of BAD and caspases-9 and -3 may be responsible for the EGFR inhibition-induced apoptosis. The EGFR physically associated with receptor activator of nuclear factor-κB (RANK) and Grb2-associated binder 2 (Gab2). Moreover, RANKL transactivated EGFR. These data indicate that EGFR regulates RANKL-activated signaling pathways by cross-talking with RANK, suggesting that the EGFR may play a crucial role as a RANK downstream signal and/or a novel type of RANK co-receptor in osteoclast differentiation and survival. J. Cell. Physiol. 217: 409–422, 2008. © 2008 Wiley-Liss, Inc." @default.
• W2078978286 created "2016-06-24" @default.
• W2078978286 creator A5006589634 @default.
• W2078978286 creator A5013003824 @default.
• W2078978286 creator A5032731408 @default.
• W2078978286 creator A5039271899 @default.
• W2078978286 creator A5060413241 @default.
• W2078978286 creator A5067428190 @default.
• W2078978286 creator A5083986477 @default.
• W2078978286 creator A5084906661 @default.
• W2078978286 creator A5088111534 @default.
• W2078978286 creator A5089329487 @default.
• W2078978286 date "2008-11-01" @default.
• W2078978286 modified "2023-10-11" @default.
• W2078978286 title "Epidermal growth factor receptor regulates osteoclast differentiation and survival through cross-talking with RANK signaling" @default.
• W2078978286 cites W1534645474 @default.
• W2078978286 cites W1544215724 @default.
• W2078978286 cites W1572873372 @default.
• W2078978286 cites W1608167574 @default.
• W2078978286 cites W1944909911 @default.
• W2078978286 cites W1960171220 @default.
• W2078978286 cites W1964066819 @default.
• W2078978286 cites W1964321121 @default.
• W2078978286 cites W1972001482 @default.
• W2078978286 cites W1981493299 @default.
• W2078978286 cites W1982186905 @default.
• W2078978286 cites W1994403682 @default.
• W2078978286 cites W1994764197 @default.
• W2078978286 cites W2002199803 @default.
• W2078978286 cites W2004717835 @default.
• W2078978286 cites W2007765297 @default.
• W2078978286 cites W2008940139 @default.
• W2078978286 cites W2010298858 @default.
• W2078978286 cites W2015946454 @default.
• W2078978286 cites W2017372504 @default.
• W2078978286 cites W2017884068 @default.
• W2078978286 cites W2023245305 @default.
• W2078978286 cites W2025128018 @default.
• W2078978286 cites W2027872174 @default.
• W2078978286 cites W2030573603 @default.
• W2078978286 cites W2034921169 @default.
• W2078978286 cites W2037669016 @default.
• W2078978286 cites W2041177539 @default.
• W2078978286 cites W2048299560 @default.
• W2078978286 cites W2057713336 @default.
• W2078978286 cites W2064603645 @default.
• W2078978286 cites W2069637592 @default.
• W2078978286 cites W2075669011 @default.
• W2078978286 cites W2076974856 @default.
• W2078978286 cites W2086022377 @default.
• W2078978286 cites W2090789303 @default.
• W2078978286 cites W2093252878 @default.
• W2078978286 cites W2098085126 @default.
• W2078978286 cites W2100359187 @default.
• W2078978286 cites W2106766464 @default.
• W2078978286 cites W2107958457 @default.
• W2078978286 cites W2111693820 @default.
• W2078978286 cites W2112157043 @default.
• W2078978286 cites W2114935509 @default.
• W2078978286 cites W2119362790 @default.
• W2078978286 cites W2120062207 @default.
• W2078978286 cites W2123303833 @default.
• W2078978286 cites W2126833898 @default.
• W2078978286 cites W2134989772 @default.
• W2078978286 cites W2136857252 @default.
• W2078978286 cites W2136986846 @default.
• W2078978286 cites W2150603117 @default.
• W2078978286 cites W2155223320 @default.
• W2078978286 cites W2157447805 @default.
• W2078978286 cites W2163070470 @default.
• W2078978286 cites W2163131714 @default.
• W2078978286 doi "https://doi.org/10.1002/jcp.21511" @default.
• W2078978286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18543257" @default.
• W2078978286 hasPublicationYear "2008" @default.
• W2078978286 type Work @default.
• W2078978286 sameAs 2078978286 @default.
• W2078978286 citedByCount "79" @default.
• W2078978286 countsByYear W20789782862012 @default.
• W2078978286 countsByYear W20789782862013 @default.
• W2078978286 countsByYear W20789782862014 @default.
• W2078978286 countsByYear W20789782862015 @default.
• W2078978286 countsByYear W20789782862016 @default.
• W2078978286 countsByYear W20789782862017 @default.
• W2078978286 countsByYear W20789782862018 @default.
• W2078978286 countsByYear W20789782862019 @default.
• W2078978286 countsByYear W20789782862020 @default.
• W2078978286 countsByYear W20789782862021 @default.
• W2078978286 countsByYear W20789782862022 @default.
• W2078978286 countsByYear W20789782862023 @default.
• W2078978286 crossrefType "journal-article" @default.
• W2078978286 hasAuthorship W2078978286A5006589634 @default.
• W2078978286 hasAuthorship W2078978286A5013003824 @default.
• W2078978286 hasAuthorship W2078978286A5032731408 @default.
• W2078978286 hasAuthorship W2078978286A5039271899 @default.
• W2078978286 hasAuthorship W2078978286A5060413241 @default.
• W2078978286 hasAuthorship W2078978286A5067428190 @default.
• W2078978286 hasAuthorship W2078978286A5083986477 @default.
• W2078978286 hasAuthorship W2078978286A5084906661 @default.

• next