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- W2078981558 abstract "Tetrahydrobiopterin (BH 4 ) is an essential cofactor for the aromatic amino acid hydroxylases, which are essential in the formation of neurotransmitters, and for nitric oxide synthase. It is presently used clinically to treat some forms of phenylketonuria (PKU) that can be ameliorated by BH 4 supplementation. Recent evidence supports potential cardiovascular benefits from BH 4 replacement for the treatment of hypertension, ischemia-reperfusion injury, and cardiac hypertrophy with chamber remodeling. Such disorders exhibit BH 4 depletion because of its oxidation and/or reduced synthesis, which can result in functional uncoupling of nitric oxide synthase (NOS). Uncoupled NOS generates more oxygen free radicals and less nitric oxide, shifting the nitroso-redox balance and having adverse consequences on the cardiovascular system. While previously difficult to use as a treatment because of chemical instability and cost, newer methods to synthesize stable BH4 suggest its novel potential as a therapeutic agent. This review discusses the biochemistry, physiology, and evolving therapeutic potential of BH4 for cardiovascular disease." @default.
- W2078981558 created "2016-06-24" @default.
- W2078981558 creator A5062089481 @default.
- W2078981558 creator A5081031540 @default.
- W2078981558 date "2006-11-01" @default.
- W2078981558 modified "2023-09-24" @default.
- W2078981558 title "Tetrahydrobiopterin and Cardiovascular Disease" @default.
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- W2078981558 doi "https://doi.org/10.1161/01.atv.0000243924.00970.cb" @default.
- W2078981558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16946131" @default.
- W2078981558 hasPublicationYear "2006" @default.
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