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- W2078981627 abstract "We evaluated the interaction effects between the estrogen receptor alpha gene (ER-alpha), vitamin D receptor gene (VDR), age and sex on bone mineral density (BMD) in a sample of 340 unrelated males and 297 unrelated females from 401 Chinese nuclear families. Polymorphisms of PvuII and XbaI in the ER-alpha gene and ApaI in the VDR gene were detected by RFLP, and ER-alpha genotype was defined by the haplotype reconstructed according to the two loci. In the females, significant ER-VDR gene interaction ( P<0.05) was found on the lumbar spine BMD. Such interaction might account for approximately 1.0% of the BMD variation. At the femoral neck and trochanter, significant ER-age interaction effects were observed, which might explain 0.3% BMD variation for both skeletal sites. In the males, significant VDR-age interaction was found on femoral neck BMD ( P<0.05), and it accounted for 0.6% BMD variation. These interaction effects were largely dependent on gender groups, suggesting there may exist ER-VDR-sex, ER-age-sex, and VDR-age-sex complex interactions in our Chinese sample." @default.
- W2078981627 created "2016-06-24" @default.
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- W2078981627 date "2003-09-19" @default.
- W2078981627 modified "2023-10-18" @default.
- W2078981627 title "Interaction effects between estrogen receptor α gene, vitamin D receptor gene, age, and sex on bone mineral density in Chinese" @default.
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- W2078981627 doi "https://doi.org/10.1007/s10038-003-0068-5" @default.
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