FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078985723> ?p ?o ?g. }

• W2078985723 abstract "Myc proteins function in heterodimeric complexes with Max proteins as transcriptional regulators at least in part by binding to E box sequences with a 5'-CACGTG core. Since such E boxes are found frequently in the human genome and since other proteins besides Myc/Max can bind to similar or identical sequences it is unclear how the specificity of E box-mediated gene transcription is determined. Recent findings were interpreted to suggest that Myc/Max, but not Max/Max or USF complexes, bind cooperatively to DNA sequences that contain two E box elements. This provides a potential mechanism for selective E box-mediated gene transcription. To extend this finding we analyzed DNA binding of c-Myc/Max complexes using a transient COS-7 expression system. In both competition and titration experiments no cooperative binding of c-Myc/Max heterodimers to probes with two E boxes was observed. Furthermore, c-Myc-specific transcription of reporter gene constructs did not reveal cooperativity. Thus ourfindings argue against cooperative DNA binding of Myc proteins as a selection mechanism for E box-dependent transcription." @default.
• W2078985723 created "2016-06-24" @default.
• W2078985723 creator A5015086682 @default.
• W2078985723 creator A5041462448 @default.
• W2078985723 date "1999-01-13" @default.
• W2078985723 modified "2023-09-26" @default.
• W2078985723 title "DNA Binding of Myc/Max/Mad Network Complexes to Oligonucleotides Containing Two E Box Elements: c-Myc/Max Heterodimers Do Not Bind DNA Cooperatively" @default.
• W2078985723 cites W1509850974 @default.
• W2078985723 cites W1547608553 @default.
• W2078985723 cites W182248608 @default.
• W2078985723 cites W1902193863 @default.
• W2078985723 cites W1953035097 @default.
• W2078985723 cites W1974521227 @default.
• W2078985723 cites W1974744327 @default.
• W2078985723 cites W1982172428 @default.
• W2078985723 cites W1997614722 @default.
• W2078985723 cites W2004205790 @default.
• W2078985723 cites W2007021266 @default.
• W2078985723 cites W2016683877 @default.
• W2078985723 cites W2020119517 @default.
• W2078985723 cites W2037632802 @default.
• W2078985723 cites W2053901722 @default.
• W2078985723 cites W2084007849 @default.
• W2078985723 cites W2086345417 @default.
• W2078985723 cites W2097774235 @default.
• W2078985723 cites W2145344972 @default.
• W2078985723 cites W2155625886 @default.
• W2078985723 cites W2158444598 @default.
• W2078985723 cites W2163859996 @default.
• W2078985723 cites W2320732213 @default.
• W2078985723 doi "https://doi.org/10.1515/bc.1999.140" @default.
• W2078985723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10543451" @default.
• W2078985723 hasPublicationYear "1999" @default.
• W2078985723 type Work @default.
• W2078985723 sameAs 2078985723 @default.
• W2078985723 citedByCount "8" @default.
• W2078985723 countsByYear W20789857232014 @default.
• W2078985723 countsByYear W20789857232015 @default.
• W2078985723 crossrefType "journal-article" @default.
• W2078985723 hasAuthorship W2078985723A5015086682 @default.
• W2078985723 hasAuthorship W2078985723A5041462448 @default.
• W2078985723 hasConcept C101762097 @default.
• W2078985723 hasConcept C104317684 @default.
• W2078985723 hasConcept C107824862 @default.
• W2078985723 hasConcept C111936080 @default.
• W2078985723 hasConcept C129312508 @default.
• W2078985723 hasConcept C138885662 @default.
• W2078985723 hasConcept C150194340 @default.
• W2078985723 hasConcept C153911025 @default.
• W2078985723 hasConcept C166014724 @default.
• W2078985723 hasConcept C179926584 @default.
• W2078985723 hasConcept C185592680 @default.
• W2078985723 hasConcept C187250156 @default.
• W2078985723 hasConcept C3662595 @default.
• W2078985723 hasConcept C41895202 @default.
• W2078985723 hasConcept C54355233 @default.
• W2078985723 hasConcept C552990157 @default.
• W2078985723 hasConcept C76753757 @default.
• W2078985723 hasConcept C86339819 @default.
• W2078985723 hasConcept C86803240 @default.
• W2078985723 hasConcept C94966510 @default.
• W2078985723 hasConceptScore W2078985723C101762097 @default.
• W2078985723 hasConceptScore W2078985723C104317684 @default.
• W2078985723 hasConceptScore W2078985723C107824862 @default.
• W2078985723 hasConceptScore W2078985723C111936080 @default.
• W2078985723 hasConceptScore W2078985723C129312508 @default.
• W2078985723 hasConceptScore W2078985723C138885662 @default.
• W2078985723 hasConceptScore W2078985723C150194340 @default.
• W2078985723 hasConceptScore W2078985723C153911025 @default.
• W2078985723 hasConceptScore W2078985723C166014724 @default.
• W2078985723 hasConceptScore W2078985723C179926584 @default.
• W2078985723 hasConceptScore W2078985723C185592680 @default.
• W2078985723 hasConceptScore W2078985723C187250156 @default.
• W2078985723 hasConceptScore W2078985723C3662595 @default.
• W2078985723 hasConceptScore W2078985723C41895202 @default.
• W2078985723 hasConceptScore W2078985723C54355233 @default.
• W2078985723 hasConceptScore W2078985723C552990157 @default.
• W2078985723 hasConceptScore W2078985723C76753757 @default.
• W2078985723 hasConceptScore W2078985723C86339819 @default.
• W2078985723 hasConceptScore W2078985723C86803240 @default.
• W2078985723 hasConceptScore W2078985723C94966510 @default.
• W2078985723 hasIssue "9" @default.
• W2078985723 hasLocation W20789857231 @default.
• W2078985723 hasLocation W20789857232 @default.
• W2078985723 hasOpenAccess W2078985723 @default.
• W2078985723 hasPrimaryLocation W20789857231 @default.
• W2078985723 hasRelatedWork W182248608 @default.
• W2078985723 hasRelatedWork W1988209556 @default.
• W2078985723 hasRelatedWork W2000508981 @default.
• W2078985723 hasRelatedWork W2025438239 @default.
• W2078985723 hasRelatedWork W2025715184 @default.
• W2078985723 hasRelatedWork W2036626789 @default.
• W2078985723 hasRelatedWork W2042777921 @default.
• W2078985723 hasRelatedWork W2053825685 @default.
• W2078985723 hasRelatedWork W207879707 @default.
• W2078985723 hasRelatedWork W2081755189 @default.
• W2078985723 hasRelatedWork W2086345417 @default.
• W2078985723 hasRelatedWork W2092376877 @default.
• W2078985723 hasRelatedWork W2093479534 @default.
• W2078985723 hasRelatedWork W2094332231 @default.

• next