FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078986972> ?p ?o ?g. }

• W2078986972 endingPage "252" @default.
• W2078986972 startingPage "247" @default.
• W2078986972 abstract "Nucleotide oligomerization domain 2 (NOD2) is a cytosolic pattern recognition receptor (PRR) that responds to muramyldipeptide (MDP), a component of peptidoglycans of gram positive and negative bacteria. NOD2 is involved in the modulation of signaling pathways for other PRRs, such as Toll-like receptors. Polymorphisms in NOD2 may evoke bowel disorders, and human Crohn's disease is significantly correlated with mis-sense insertion of the NOD2 gene. Such polymorphisms affecting ligand recognition in the NOD2 gene may also influence bowel flora in livestock, which is compromised by bowel diseases such as diarrhea. We investigated the functional variance of mis-sense polymorphisms in ligand recognition by porcine NOD2. The 1949T>C polymorphism, located in the region encoding the hinge domain of the molecule, notably diminished the functional response of porcine NOD2 to MDP. By comparison, the 2197A>C polymorphism, localized in the region corresponding to leucine-rich repeats, significantly augmented the response of porcine NOD2 to the ligand. The 1949C allele was rare among pig breeds, suggesting that this mutation is a disadvantage to pigs in their immune response to microbes. The 2197C allele, in contrast, was widely distributed among Western breeds and is most likely to be derived from wild boars in Asia. This is the first report of a causal relationship between molecular function and polymorphisms in PRRs in non-primate, non-rodent mammals. These findings suggest that the 2197C allele might confer an immune response advantage in modern pig breeds and may be a useful marker for breeding aimed at disease resistance in pigs." @default.
• W2078986972 created "2016-06-24" @default.
• W2078986972 creator A5019035608 @default.
• W2078986972 creator A5022215802 @default.
• W2078986972 creator A5026552774 @default.
• W2078986972 creator A5027724595 @default.
• W2078986972 creator A5034226675 @default.
• W2078986972 creator A5056283558 @default.
• W2078986972 creator A5056819567 @default.
• W2078986972 creator A5065497312 @default.
• W2078986972 creator A5079824996 @default.
• W2078986972 creator A5081709805 @default.
• W2078986972 creator A5084588839 @default.
• W2078986972 creator A5089155720 @default.
• W2078986972 creator A5089423187 @default.
• W2078986972 date "2009-12-01" @default.
• W2078986972 modified "2023-10-06" @default.
• W2078986972 title "Influence of polymorphisms in porcine NOD2 on ligand recognition" @default.
• W2078986972 cites W1969767037 @default.
• W2078986972 cites W2005820711 @default.
• W2078986972 cites W2012272570 @default.
• W2078986972 cites W2014679946 @default.
• W2078986972 cites W2017516541 @default.
• W2078986972 cites W2025495699 @default.
• W2078986972 cites W2028960213 @default.
• W2078986972 cites W2032959963 @default.
• W2078986972 cites W2035983710 @default.
• W2078986972 cites W2040210770 @default.
• W2078986972 cites W2052798287 @default.
• W2078986972 cites W2073731887 @default.
• W2078986972 cites W2086607027 @default.
• W2078986972 cites W2089190597 @default.
• W2078986972 cites W2111058855 @default.
• W2078986972 cites W2111919009 @default.
• W2078986972 cites W2121994948 @default.
• W2078986972 cites W2126880379 @default.
• W2078986972 cites W2131974108 @default.
• W2078986972 cites W2132482634 @default.
• W2078986972 cites W2155025594 @default.
• W2078986972 doi "https://doi.org/10.1016/j.molimm.2009.09.030" @default.
• W2078986972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19822368" @default.
• W2078986972 hasPublicationYear "2009" @default.
• W2078986972 type Work @default.
• W2078986972 sameAs 2078986972 @default.
• W2078986972 citedByCount "22" @default.
• W2078986972 countsByYear W20789869722012 @default.
• W2078986972 countsByYear W20789869722013 @default.
• W2078986972 countsByYear W20789869722014 @default.
• W2078986972 countsByYear W20789869722015 @default.
• W2078986972 countsByYear W20789869722016 @default.
• W2078986972 countsByYear W20789869722017 @default.
• W2078986972 countsByYear W20789869722018 @default.
• W2078986972 countsByYear W20789869722019 @default.
• W2078986972 countsByYear W20789869722021 @default.
• W2078986972 countsByYear W20789869722022 @default.
• W2078986972 crossrefType "journal-article" @default.
• W2078986972 hasAuthorship W2078986972A5019035608 @default.
• W2078986972 hasAuthorship W2078986972A5022215802 @default.
• W2078986972 hasAuthorship W2078986972A5026552774 @default.
• W2078986972 hasAuthorship W2078986972A5027724595 @default.
• W2078986972 hasAuthorship W2078986972A5034226675 @default.
• W2078986972 hasAuthorship W2078986972A5056283558 @default.
• W2078986972 hasAuthorship W2078986972A5056819567 @default.
• W2078986972 hasAuthorship W2078986972A5065497312 @default.
• W2078986972 hasAuthorship W2078986972A5079824996 @default.
• W2078986972 hasAuthorship W2078986972A5081709805 @default.
• W2078986972 hasAuthorship W2078986972A5084588839 @default.
• W2078986972 hasAuthorship W2078986972A5089155720 @default.
• W2078986972 hasAuthorship W2078986972A5089423187 @default.
• W2078986972 hasConcept C104317684 @default.
• W2078986972 hasConcept C111289621 @default.
• W2078986972 hasConcept C135763542 @default.
• W2078986972 hasConcept C136449434 @default.
• W2078986972 hasConcept C153209595 @default.
• W2078986972 hasConcept C180754005 @default.
• W2078986972 hasConcept C203014093 @default.
• W2078986972 hasConcept C54355233 @default.
• W2078986972 hasConcept C7573103 @default.
• W2078986972 hasConcept C86803240 @default.
• W2078986972 hasConcept C8891405 @default.
• W2078986972 hasConceptScore W2078986972C104317684 @default.
• W2078986972 hasConceptScore W2078986972C111289621 @default.
• W2078986972 hasConceptScore W2078986972C135763542 @default.
• W2078986972 hasConceptScore W2078986972C136449434 @default.
• W2078986972 hasConceptScore W2078986972C153209595 @default.
• W2078986972 hasConceptScore W2078986972C180754005 @default.
• W2078986972 hasConceptScore W2078986972C203014093 @default.
• W2078986972 hasConceptScore W2078986972C54355233 @default.
• W2078986972 hasConceptScore W2078986972C7573103 @default.
• W2078986972 hasConceptScore W2078986972C86803240 @default.
• W2078986972 hasConceptScore W2078986972C8891405 @default.
• W2078986972 hasIssue "2-3" @default.
• W2078986972 hasLocation W20789869721 @default.
• W2078986972 hasLocation W20789869722 @default.
• W2078986972 hasOpenAccess W2078986972 @default.
• W2078986972 hasPrimaryLocation W20789869721 @default.
• W2078986972 hasRelatedWork W1557412924 @default.
• W2078986972 hasRelatedWork W2032650692 @default.

• next