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- W2078987132 abstract "Several published studies have reported the clinical and economic impact of adherence to disease-modifying therapies (DMTs) for multiple sclerosis (MS), although none have examined the impact of adherence exclusively in patients continuously enrolled for five years. The objectives of this study were to understand some of the clinical and economic outcomes associated with long-term adherence/non-adherence to DMTs in MS patients. Patients who had a medical or pharmacy claim for a DMT between January 1, 2005 to December 31, 2005 and who were continuously enrolled until December 31, 2011 were included in this retrospective cohort study. A total of 664 patients met eligibility criteria, and were defined as adherent if they had a medication possession ratio (MPR) of greater than 80% in all five years. Propensity Score Bin-Bootstrapping method was used to control for the variation between the adherent and non-adherent groups. Variables used to calculate propensity scores were age, gender, comorbidities and severity of disease. Compared with the non-adherent group, the adherent group had significantly fewer inpatient relapses per year (0.339 vs. 0.215, p<0.01) and had lower annual unadjusted medical costs. The non-adherent group had significantly higher (p<0.05) adjusted annual medical costs than their matched adherent counterparts in all 5 years of the study, except for year 1. From year 1 to year 5, adjusted medical costs increased 235% in the non-adherent group compared to 93% in the adherent group. MS patients with consistently high medication adherence to DMTs over a 5 year period had lower rates of inpatient relapse and lower total medical costs than their non-adherent counterparts. Given the high cost of DMTs to both payers and patients, it is imperative to support and encourage high adherence when using these agents in order to get the most value out of the investment in DMTs." @default.
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- W2078987132 date "2013-05-01" @default.
- W2078987132 modified "2023-10-15" @default.
- W2078987132 title "Clinical and economic impact of five-year adherence to disease-modifying therapies in a commercially insured multiple sclerosis population" @default.
- W2078987132 doi "https://doi.org/10.1016/j.jval.2013.03.517" @default.
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