FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078987799> ?p ?o ?g. }

• W2078987799 endingPage "102" @default.
• W2078987799 startingPage "95" @default.
• W2078987799 abstract "A prospective study was carried out over 12 months involving twenty patients with psoriasis vulgaris who were treated with all-trans-aromatic derivative of vitamin A, etretinate. Etretinate was found to be an effective therapy for this skin disorder. Arthritis accompanying psoriasis vulgaris in four of seven of our patients was greatly improved by retinoid therapy. Side effects were found to be dose-related and included mucocutaneous abnormalities as well as abnormalities of blood lipids and liver function tests. Maintenance therapy appears to be required in nearly all patients, with relapse occurring within approximately 8 weeks. Polyamine biosynthesis has been determined previously to be accelerated in patients with psoriasis vulgaris. Polyamines (putrescine [Pu], spermidine [Sp], and spermine [Sm]) were measured in skin samples of six patients with stable plaque-stage psoriasis before treatment and at 4 weeks during treatment. Pu, Sp, Sm levels, as well as the Sp/Sm ratio, fell. Epidermal DNA synthesis is increased in involved and noninvolved psoriatic skin; it was measured before and during treatment (at 4 weeks) in this study and found not to fall significantly during this period of time. Polyamine levels therefore decreased prior to any significant expected decrease in epidermal DNA synthesis measured in both involved and uninvolved skin. A prospective study was carried out over 12 months involving twenty patients with psoriasis vulgaris who were treated with all-trans-aromatic derivative of vitamin A, etretinate. Etretinate was found to be an effective therapy for this skin disorder. Arthritis accompanying psoriasis vulgaris in four of seven of our patients was greatly improved by retinoid therapy. Side effects were found to be dose-related and included mucocutaneous abnormalities as well as abnormalities of blood lipids and liver function tests. Maintenance therapy appears to be required in nearly all patients, with relapse occurring within approximately 8 weeks. Polyamine biosynthesis has been determined previously to be accelerated in patients with psoriasis vulgaris. Polyamines (putrescine [Pu], spermidine [Sp], and spermine [Sm]) were measured in skin samples of six patients with stable plaque-stage psoriasis before treatment and at 4 weeks during treatment. Pu, Sp, Sm levels, as well as the Sp/Sm ratio, fell. Epidermal DNA synthesis is increased in involved and noninvolved psoriatic skin; it was measured before and during treatment (at 4 weeks) in this study and found not to fall significantly during this period of time. Polyamine levels therefore decreased prior to any significant expected decrease in epidermal DNA synthesis measured in both involved and uninvolved skin." @default.
• W2078987799 created "2016-06-24" @default.
• W2078987799 creator A5043646240 @default.
• W2078987799 creator A5052668530 @default.
• W2078987799 creator A5072890715 @default.
• W2078987799 date "1983-01-01" @default.
• W2078987799 modified "2023-09-23" @default.
• W2078987799 title "Etretinate therapy for psoriasis: Clinical responses, remission times, epidermal DNA and polyamine responses" @default.
• W2078987799 cites W1963906676 @default.
• W2078987799 cites W1964056251 @default.
• W2078987799 cites W1967346869 @default.
• W2078987799 cites W1971519806 @default.
• W2078987799 cites W1980755112 @default.
• W2078987799 cites W1998883236 @default.
• W2078987799 cites W2001692500 @default.
• W2078987799 cites W2004590567 @default.
• W2078987799 cites W2041481147 @default.
• W2078987799 cites W2061709864 @default.
• W2078987799 cites W2067327580 @default.
• W2078987799 cites W2072117102 @default.
• W2078987799 cites W2077317103 @default.
• W2078987799 cites W2089338597 @default.
• W2078987799 cites W2089779191 @default.
• W2078987799 cites W2093458726 @default.
• W2078987799 cites W2163396453 @default.
• W2078987799 doi "https://doi.org/10.1016/s0190-9622(83)70012-5" @default.
• W2078987799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6826812" @default.
• W2078987799 hasPublicationYear "1983" @default.
• W2078987799 type Work @default.
• W2078987799 sameAs 2078987799 @default.
• W2078987799 citedByCount "71" @default.
• W2078987799 countsByYear W20789877992018 @default.
• W2078987799 crossrefType "journal-article" @default.
• W2078987799 hasAuthorship W2078987799A5043646240 @default.
• W2078987799 hasAuthorship W2078987799A5052668530 @default.
• W2078987799 hasAuthorship W2078987799A5072890715 @default.
• W2078987799 hasConcept C126322002 @default.
• W2078987799 hasConcept C134018914 @default.
• W2078987799 hasConcept C16005928 @default.
• W2078987799 hasConcept C181199279 @default.
• W2078987799 hasConcept C188816634 @default.
• W2078987799 hasConcept C2776705134 @default.
• W2078987799 hasConcept C2777497464 @default.
• W2078987799 hasConcept C2780115381 @default.
• W2078987799 hasConcept C2780564577 @default.
• W2078987799 hasConcept C55493867 @default.
• W2078987799 hasConcept C71924100 @default.
• W2078987799 hasConcept C86803240 @default.
• W2078987799 hasConcept C90924648 @default.
• W2078987799 hasConceptScore W2078987799C126322002 @default.
• W2078987799 hasConceptScore W2078987799C134018914 @default.
• W2078987799 hasConceptScore W2078987799C16005928 @default.
• W2078987799 hasConceptScore W2078987799C181199279 @default.
• W2078987799 hasConceptScore W2078987799C188816634 @default.
• W2078987799 hasConceptScore W2078987799C2776705134 @default.
• W2078987799 hasConceptScore W2078987799C2777497464 @default.
• W2078987799 hasConceptScore W2078987799C2780115381 @default.
• W2078987799 hasConceptScore W2078987799C2780564577 @default.
• W2078987799 hasConceptScore W2078987799C55493867 @default.
• W2078987799 hasConceptScore W2078987799C71924100 @default.
• W2078987799 hasConceptScore W2078987799C86803240 @default.
• W2078987799 hasConceptScore W2078987799C90924648 @default.
• W2078987799 hasIssue "1" @default.
• W2078987799 hasLocation W20789877991 @default.
• W2078987799 hasLocation W20789877992 @default.
• W2078987799 hasOpenAccess W2078987799 @default.
• W2078987799 hasPrimaryLocation W20789877991 @default.
• W2078987799 hasRelatedWork W1546465212 @default.
• W2078987799 hasRelatedWork W1555612246 @default.
• W2078987799 hasRelatedWork W1971817054 @default.
• W2078987799 hasRelatedWork W1998041015 @default.
• W2078987799 hasRelatedWork W2022573319 @default.
• W2078987799 hasRelatedWork W2078987799 @default.
• W2078987799 hasRelatedWork W2083823562 @default.
• W2078987799 hasRelatedWork W2619666191 @default.
• W2078987799 hasRelatedWork W4237919213 @default.
• W2078987799 hasRelatedWork W4243112293 @default.
• W2078987799 hasVolume "8" @default.
• W2078987799 isParatext "false" @default.
• W2078987799 isRetracted "false" @default.
• W2078987799 magId "2078987799" @default.
• W2078987799 workType "article" @default.